Systems, methods and computer-readable medium for determining depth-resolved physical and/or optical properties of scattering media by analyzing measured data over a range of depths

• US 8,721,077 B2
• Filed: 04/26/2012
• Issued: 05/13/2014
• Est. Priority Date: 04/29/2011
• Status: Active Grant

• Current Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Original Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Inventors: Vermeer, Koenraad Arndt, De Boer, Johannes Fitzgerald
• Primary Examiner(s): HASAN, MOHAMMED A
• Application Number:
  US13/456,541
• Publication Number:
  US 20120274896A1
• Time in Patent Office: 747 Days
• Field of Search: 351200-246
• US Class Current: 351/205
• CPC Class Codes: A61B 3/102 for optical coherence tomography [OCT]
• CPC Class Codes: A61B 8/10 Eye inspection
• CPC Class Codes: G01B 9/02083 characterised by particular signal processing and presentation
• CPC Class Codes: G01B 9/02091 Tomographic interferometers, e.g. based on optical coherence
• CPC Class Codes: G01N 2021/4709 Backscatter
• CPC Class Codes: G01N 21/47 Scattering, i.e. diffuse reflection G01N21/25, G01N21/41 take precedence G01N21/55 takes precedence
• CPC Class Codes: G01N 21/4795 spatially resolved investigating of object in scattering medium in vivo A61B

Abstract

In depth-resolved imaging of scattering media, incident light interacts with tissue in a complex way before the signal reaches the detector: Light interacts with media between the light source and a specific depth, then scatters at that depth and the backscattered light again interacts with media on its way to the detector. The resulting depth-resolved signal therefore likely does not directly represent a physical or optical property of the media at those depths. Exemplary systems, methods and computer-accessible medium can determine physical or optical properties based on such depth-resolved signals. For example, almost all the light can interact with the media, and that the energy of the incident light at a certain depth is likely therefore related to the integral of the scattered light from all deeper locations. Based on the detected signals, the properties of the media can be estimated in an iterative way.

Claims

1. A method for determining at least one property of at least one biological structure, comprising:

(a) obtaining a plurality of signals received at particular depths within the at least one biological structure, wherein at least first one of the signals is obtained from a first depth of the particular depths, and at least second one of the signals is obtained from a second depth of the particular depths, the first and second depths being different from one another;

(b) determining information based on the signals and an assumed property of the at least one biological structure; and

(c) determining at least one calculated property based on the information by excluding at least a portion of the information associated with the signals provided from the particular depths that are closer than a predetermined depth within the at least one biological structure, wherein the calculated property is an attenuation property.

2. The method according to claim 1, further comprising:

(d) repeating procedures (b) and (c) at least once, such that, in procedure (b), the assumed property is replaced with the calculated property of procedure (c) to obtain the at least one property of the at least one biological structure.

3. The method according to claim 1, wherein the signals are optical coherence tomography signals or ultrasound signals.

4. The method according to claim 1, wherein the at least one calculated property includes local optical properties of scattering media of the at least one biological structure, and wherein the local optical properties are determined using the information from a range of the particular depths.

5. The method according to claim 4, wherein the local optical properties are determined using the information obtained from the depth which is a shallower depth and the information obtained at the second depth which is a larger depth.

6. The method according to claim 5, further comprising summing the information obtained from the second depth to obtain an estimate of an intensity of a radiation forwarded to the at least one structure,

7. The method according to claim 1, wherein the information is a local backscattered energy from the at least one structure.

8. The method according to claim 7, wherein the local backscattered energy is measured by an optical coherence tomography procedure.

9. The method according to claim 4, wherein the local optical property includes an attenuation coefficient.

10. The method according to claim 4, wherein the at least one calculated property includes at least one optical property or at least one physical property which are iteratively determined from the information to be estimate at various depths within the at least one structure.

11. The method according to claim 4, wherein the at least one calculated property is used for diagnosis or for at least one of a manual segmentation or an automatic segmentation.

12. The method according to claim 1, wherein the at least one calculated property includes a calculated attenuation.

13. The method according to claim 1, wherein the assumed property is an assumed attenuation.

14. A system for determining at least one property of at least one biological structure, comprising:

at least one first arrangement which is configured to obtain a plurality of signals received at particular depths within the at least one biological structure, wherein at least first one of the signals is obtained from a first depth of the particular depths, and at least second one of the signals is obtained from a second depth of the particular depths, the first and second depths being different from one another; and

at least one second computing arrangement which is configured to determine;

information based on the signals and an assumed property of the at least one biological structure; and

at least one calculated property based on the information by excluding at least a portion of the information associated with the signals provided from the particular depths that are closer than a predetermined depth within the at least one biological structure, wherein the at least one calculated property is an attenuation property,

15. The system according to claim 14, wherein the at least one second computing arrangement is further configured to:

(d) repeat procedures (h) and (c) at least once, such that, in procedure (b), the at least one second computing arrangement causes a replacement of the assumed property with the calculated property of procedure (c) to obtain the at least one property of the at least one biological structure.

16. The system according to claim 14, wherein the signals are optical coherence tomography signals or ultrasound signals.

17. The system according to claim 14, wherein the at least one calculated property includes local optical properties of scattering media of the at least one biological structure, and wherein the at least one second computing arrangement is further configured to determine the local optical properties using the information from a range of the particular depths.

18. The system according to claim 17, wherein the at least one second computing arrangement is configured to determine the local optical properties using the information obtained from the depth which is a shallower depth and the information obtained at the second depth which is a larger depth.

19. The system according to claim 18, wherein the at least one second computing arrangement is further configured to sum the information obtained from the second depth to obtain an estimate of an intensity of a radiation forwarded to the at least one structure.

20. The system according to claim 14, wherein the information is a local backscattered energy from the at least one structure.

21. The system according to claim 20, wherein the local backscattered energy is measured by an optical coherence tomography procedure,

22. The system according to claim 17, wherein the local optical property includes an attenuation coefficient.

23. The system according to claim 17, wherein the at least one calculated property includes at least one optical property or at least one physical property, and wherein the at least one second computing arrangement is further configured to iteratively the at least one calculated property from the information to be estimate at various depths within the at least one structure.

24. The system according to claim 17, wherein the at least one second computing arrangement is further configured to use the at least one calculated property for diagnosis or for at least one of a manual segmentation or an automatic segmentation.

25. The system according to claim 14, wherein the at least one calculated property includes a calculated attenuation.

26. The system according to claim 14, wherein the assumed property is an assumed attenuation.

27. A non-transitory computer accessible medium which includes software thereon for determining at least one property of at least one biological structure, wherein, when a computing arrangement executes the software, the computing arrangement is configured to perform procedures comprising:

(a) cause a plurality of signals received at particular depths within the at least one biological structure to be received, wherein at least first one of the signals is obtained from a first depth of the particular depths, and at least second one of the signals is obtained from a second depth of the particular depths, the first and second depths being different from one another;

(b) determine information based on the signals and an assumed property of the at least one biological structure; and

(c) determine at least one calculated property based on the information by excluding at least a portion of the information associated with the signals provided from the particular depths that are closer than a predetermined depth within the at least one biological structure, wherein the calculated property is an attenuation property.