Therapeutic compositions

  • US 8,735,375 B2
  • Filed: 02/18/2013
  • Issued: 05/27/2014
  • Est. Priority Date: 12/16/2005
  • Status: Active Grant
First Claim
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1. A method of treating skin cancer in a subject in need thereof, the method comprising topically administering a therapeutically effective amount of a pharmaceutical formulation of ingenol angelate to the skin of the subject, wherein the pharmaceutical formulation comprises ingenol angelate in an amount from about 0.001% to about 0.15% w/w, and wherein at least about 97.5% of the ingenol angelate is ingenol-3-angelate (isoform ‘

  • b’

    ) and the pharmaceutical formulation has a pH of less than 4.

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