Multiple independent nested stent structures and methods for their preparation and deployment

• US 8,740,968 B2
• Filed: 08/30/2012
• Issued: 06/03/2014
• Est. Priority Date: 01/17/2003
• Status: Expired due to Fees

• Current Assignee: JW Medical Systems Ltd
• Original Assignee: JW Medical Systems Ltd
• Inventors: Kao, Stephen, Andreas, Bernard, Gifford, Hanson S. III, Deem, Mark E., Snow, David W., Grainger, Jeffry J.
• Primary Examiner(s): Holwerda, Kathleen
• Assistant Examiner(s): TANNER, JOCELIN C
• Application Number:
  US13/599,957
• Publication Number:
  US 20130060321A1
• Time in Patent Office: 642 Days
• Field of Search: 623/1.11, 623/1.15, 623/1.16, 623 142- 148, 623/1.12, 606/194, 606/108, 604/101.01, 604/101.05
• US Class Current: 623/1.16
• CPC Class Codes: A61F 2/91 made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
• CPC Class Codes: A61F 2/915 with bands having a meander structure, adjacent bands being connected to each other
• CPC Class Codes: A61F 2/95 Instruments specially adapted for placement or removal of stents or stent-grafts
• CPC Class Codes: A61F 2002/826 more than one stent being applied sequentially
• CPC Class Codes: A61F 2002/828 Means for connecting a plurality of stents allowing flexibility of the whole structure
• CPC Class Codes: A61F 2002/91508 the meander having a difference in amplitude along the band
• CPC Class Codes: A61F 2002/91516 the meander having a change in frequency along the band
• CPC Class Codes: A61F 2002/91525 within the whole structure different bands showing different meander characteristics, e.g. frequency or amplitude
• CPC Class Codes: A61F 2002/91533 characterised by the phase between adjacent bands
• CPC Class Codes: A61F 2002/9155 Adjacent bands being connected to each other
• CPC Class Codes: A61F 2002/9583 Means for holding the stent on the balloon, e.g. using protrusions, adhesives or an outer sleeve

Abstract

Blood vessels and other body lumens are stented using stent structures comprising a plurality of radially expansible rings where at least some of the rings comprise axially extending elements which interleave with axially extending elements on adjacent unconnected rings. The ring structures may be open cell structures or closed cell structures, and the axially extending elements will typically be formed as part of the open cell or closed cell structure.

Claims

1. A method for arranging multiple independent stent rings on a carrier of a catheter, said method comprising:

providing an elongated carrier structure; and

mounting a plurality of radially expansible rings comprising axially extending elements on the carrier structure with the rings in an unexpanded crimped configuration suitable for delivery into a blood vessel and at least some of the rings are separable from an adjacent ring, wherein the axially extending elements on adjacent rings interleave when mounted on the carrier structure in the unexpanded crimped configuration without interlocking so as to permit axial separation of the adjacent rings, none of the axially extending elements constraining axial separation of the adjacent rings in the unexpanded crimped configuration, wherein the axially extending elements having an overlapping portion which is received between axially extending elements of an adjacent ring, the overlapping portion comprising a pair of axial struts separated by a circumferential distance which is constant or tapering toward the adjacent ring throughout all of the overlapping portion, wherein at least some of the axially extending elements comprise expansible closed structures which widen as the rings are expanded and wherein at least some of the axially separable rings further comprise spacers which engage the axially extending elements on adjacent rings to provide a preselected spacing between adjacent rings upon radial expansion, wherein adjacent axially extending elements form a concave region therebetween, the concave region having a closed end and the spacers maintaining a gap between the closed end and an axially extending element of the adjacent ring, wherein the spacers comprise an axially extending strut having an axial extension length, the axially extending strut being disposed between two adjacent axially extending elements on the same ring, the two adjacent axially extending elements having an axial length greater than the axial extension length of the strut.

2. A method as in claim 1, wherein the number of rings mounted on the carrier structure is selected to provide a desired overall stent length.

3. A method as in claim 2, wherein the number of rings is from two to 50 and the overall stent length is in the range from 2 mm to 200 mm.

4. A method as in claim 1, wherein the expansible closed structures are selected from the group consisting of boxes, rhomboids, ovals, ellipses, diamonds, and irregular polygons.

5. A method as in claim 1, wherein the expansible closed structures are defined by a slot pattern selected from the group consisting of I-patterns and H-patterns, and J-patterns.

6. A method as in claim 1, wherein the radially expansible rings are configured to axially shorten upon expansion.

7. A method as in claim 1, wherein the axially extending elements remain interleaved following expansion.

8. A method as in claim 1, wherein the axially extending elements axially interleave over a distance of at least 0.1 mm prior to stent expansion.

9. A method as in claim 8, wherein the distance is in the range from 1 mm to 5 mm.

10. A method as in claim 1, wherein the rings have axial lengths in range from 1 mm to 10 mm, prior to radial expansion.

11. A method as in claim 10, wherein the rings have axial lengths in the range from 0.9 mm to 9 mm after radial expansion.

12. A method as in claim 11 consisting of from two to 50 expansible ring structures.

13. A method as in claim 1, wherein the radially expansible rings releasably carry a biologically active agent.

14. A method as in claim 13, wherein the biologically active agent inhibits hyperplasia.

15. A method as in claim 14, wherein the biologically active agent is selected from the group consisting of anti-neoplastic drugs including paclitaxel, methotrexate and batimastal;

antibiotics including doxycycline, tetracycline, rapamycin, and actinomycin;

immunosuppressants including dexamethasone and methyl prednisolone;

nitric oxide sources including nitroprussides;

estrogen; and

estradiols.

16. A method as in claim 1, further comprising covering at least a portion of the rings with a carrier tube coupled to the carrier structure.

17. A method as in claim 1, wherein the rings are mounted on an elongated balloon coupled to the carrier structure.

18. A method as in claim 17, wherein the rings are axially slidable on the elongated balloon.

19. A method as in claim 1, wherein the spacer comprises a cradle structure adapted to receive an axially extending element on an adjacent ring.

20. A method as in claim 1, wherein the spacer comprises a concave abutment.