Methods of coating an implantable device
First Claim
Patent Images
1. A method of coating an implantable device or an implantable portion of a medical device comprising:
- providing, on a support structure, a medical device capable of being implanted;
adjusting the temperature of the implantable medical device to a target temperature;
atomizing a coating substance with a gaseous propellant, the coating substance comprising a solvent, a polymer dissolved in the solvent, and a therapeutic substance; and
applying the coating substance onto the implantable medical device after starting the act of adjusting the temperature and while the implantable medical device is supported by the support structure,wherein the implantable medical device is not a catheter liner, the target temperature selected is below a temperature which causes thermal degradation of the therapeutic substance, andthe adjusting step ending is selected from the following;
the adjusting step ends before the applying step begins;
the adjusting step does not end before the applying step begins;
the adjusting step ends before the applying step ends; and
the adjusting step ends after the applying step ends.
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Abstract
Methods of coating an implantable device, such as a stent, are provided.
308 Citations
23 Claims
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1. A method of coating an implantable device or an implantable portion of a medical device comprising:
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providing, on a support structure, a medical device capable of being implanted; adjusting the temperature of the implantable medical device to a target temperature; atomizing a coating substance with a gaseous propellant, the coating substance comprising a solvent, a polymer dissolved in the solvent, and a therapeutic substance; and applying the coating substance onto the implantable medical device after starting the act of adjusting the temperature and while the implantable medical device is supported by the support structure, wherein the implantable medical device is not a catheter liner, the target temperature selected is below a temperature which causes thermal degradation of the therapeutic substance, and the adjusting step ending is selected from the following; the adjusting step ends before the applying step begins; the adjusting step does not end before the applying step begins; the adjusting step ends before the applying step ends; and the adjusting step ends after the applying step ends. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. A method of coating an implantable device or an implantable portion of a medical device comprising:
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providing, on a support structure, a medical device capable of being implanted; adjusting the temperature of the implantable medical device to a target temperature; atomizing a coating substance with a gaseous propellant, the coating substance comprising a solvent, a polymer dissolved in the solvent, and a therapeutic substance; and applying the coating substance onto the implantable medical device after starting the act of adjusting the temperature and while the implantable medical device is supported by the support structure, wherein the implantable medical device is not a catheter liner, the target temperature selected is below a temperature which causes thermal degradation of the therapeutic substance, and the adjusting step ending is selected from the following; the adjusting step ends before the applying step begins; the adjusting step does not end before the applying step begins; the adjusting step ends before the applying step ends; and the adjusting step ends after the applying step ends, wherein the target temperature is below ambient temperature. - View Dependent Claims (20, 21)
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22. A method of coating an implantable device comprising:
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adjusting the temperature of the implantable device to a target temperature; and applying a coating substance, after the act of adjusting the temperature begins, comprising a volatile solvent, a polymer and a therapeutic substance, to the implantable device while the implantable device is supported by a support structure, wherein the implantable device is not a catheter liner and wherein the implantable device is a polymeric or metallic stent, wherein the adjusting step ends before the applying step begins; the adjusting step does not end before the applying step begins; the adjusting step ends before the applying step ends;
orthe adjusting step ends after the applying step ends, wherein the target temperature is less than 20°
C., andwherein the therapeutic agent inhibits, reduces, helps in diagnosis, or treats a human or animal disease; and is at least one or any combination of antibiotics;
anticoagulants;
antifibrins;
antiinflammatories;
antimitotics;
antineoplastics;
antioxidants;
antiplatelets;
antiproliferatives;
or antithrombins.
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23. A method of coating an implantable device comprising:
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adjusting the temperature of the implantable device to a target temperature; and applying a coating substance, after the act of adjusting the temperature begins, comprising a non-volatile solvent, a polymer and a therapeutic substance, to the implantable device while the implantable device is supported by a support structure, wherein the implantable device is not a catheter liner, the target temperature selected is below a temperature which causes thermal degradation of the therapeutic substance, and wherein the implantable medical device is a polymeric or metallic stent, wherein the adjusting step ends before the applying step begins; the adjusting step does not end before the applying step begins; the adjusting step ends before the applying step ends;
orthe adjusting step ends after the applying step ends, wherein the target temperature is greater than 20°
C., andwherein the therapeutic agent inhibits, reduces, diagnosis, or treats a human or animal disease; and is at least one or any combination of antibiotics;
anticoagulants;
antifibrins;
antiinflammatories;
antimitotics;
antineoplastics;
antioxidants;
antiplatelets;
antiproliferatives;
or antithrombins.
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Specification