Use of anabolic agents, anti-catabolic agents, antioxidant agents, and analgesics for protection, treatment and repair of connective tissues in humans and animals

• US 8,753,697 B2
• Filed: 09/24/2009
• Issued: 06/17/2014
• Est. Priority Date: 02/13/1998
• Status: Expired due to Fees

• Current Assignee: Nutramax Laboratories Incorporated
• Original Assignee: Nutramax Laboratories Incorporated
• Inventors: Henderson, Todd R., Hammad, Tarek, Soliman, Medhat, Corson, Barbara, Henderson, Robert, Lippiello, Louis
• Primary Examiner(s): Wang, Shengjun
• Application Number:
  US12/566,449
• Publication Number:
  US 20100105632A1
• Time in Patent Office: 1,727 Days
• Field of Search: 514/23, 514/42, 514/62, 514/55, 514/457, 424/757
• US Class Current: 424/757
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/00 Medicinal preparations containing organic active ingredients
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: A61P 19/04 for non-specific disorders of the connective tissue

Abstract

The present invention relates to compositions for the protection, treatment and repair of connective tissues in humans and animals comprising any or all of anabolic, anti-catabolic, anti-oxidant and analgesic agents, including aminosugars, S-adenosylmethionine, arachadonic acid, GAGs, including pentosan, collagen type II, tetracyclines or tetracycline-like compounds, diacerin, super oxide dismutase, L-ergothionine, one or more avocado/soybean unsaponifiables, and an analgesic, e.g., acetaminophen, and to methods of treating humans and animals by administration of these novel compositions to humans and animals in need thereof.

Claims

1. A composition comprising avocado/soybean unsaponifiables (ASU) and a glycosaminoglycan, wherein the ASU and the glycosaminoglycan are present in a synergistically effective amount.

2. The composition according to claim 1, wherein the glycosaminoglycan comprises a natural, synthetic or semi-synthetic glycosaminogly-can, a glycosaminoglycan-like compound, a glycosaminoglycan precursor or fragments of a glycosaminoglycan.

3. The composition according to claim 1, wherein the glycsosaminoglycan has been chemically modified by one or more of esterification, sulfation, polysulfation, acetylation and methylation.

4. The composition according to claim 1, wherein the glycosaminoglycan is chondroitin or a salt thereof, hyaluronic acid, or a mixture of these.

5. The composition according to claim 1, wherein the glycosaminoglycan is chondroitin sulfate.

6. The composition of claim 1, wherein a dose of the avocado/soybean unsaponifiables ranges from about 5 milligrams to about 5 grams.

7. The composition of claim 1, wherein a dose for a small animal of the avocado/soybean unsaponifiables ranges from about 5 milligrams to about 1000 milligrams.

8. The composition of claim 1, wherein a dose for a human of the avocado/soybean unsaponifiables ranges from about 50 milligrams to about 1500 milligrams.

9. The composition of claim 1, wherein a dose for a large animal of the avocado/soybean unsaponifiables ranges from about 100 milligrams to about 5 grams.

10. The composition of claim 1, wherein a dose of the avocado/soybean unsaponifiables ranges from about 1 mg/kg to about 25 mg/kg.

11. The composition of claim 1, wherein a dose of the avocado/soybean unsaponifiables for a small animal ranges from about 0.5 mg/kg to about 25 mg/kg.

12. The composition of claim 1, wherein a dose of the avocado/soybean unsaponifiables for a human ranges from about 0.5 mg/kg to about 25 mg/kg.

13. The composition of claim 1, wherein a dose of the avocado/soybean unsaponifiables for a large animal ranges from about 0.5 mg/kg to about 25 mg/kg.

14. The composition of claim 1, wherein a dose of the glycosaminoglycan component ranges from about 15 milligrams to about 12 grams.

15. The composition of claim 1, wherein a dose of the glycosaminoglycan component for a small animal ranges from about 15 milligrams to about 2 grams.

16. The composition of claim 1, wherein a dose of the glycosaminoglycan component for a human ranges from about 75 milligrams to about 4 grams.

17. The composition of claim 1, wherein a dose of the glycosaminoglycan component for a large animal ranges from about 300 milligrams to about 12 grams.

18. The composition of claim 1, wherein a dose of the glycosaminoglycan component for a small animal ranges from about 1 mg/kg to about 75 mg/kg.

19. The composition of claim 1, wherein a dose of the glycosaminoglycan component for a human ranges from about 1 mg/kg to about 75 mg/kg.

20. The composition of claim 1, wherein a dose of the glycosaminoglycan component for a large animal ranges from about 1 mg/kg to about 75 mg/kg.

21. A method of treating or repairing damage to connective tissue in humans and animals comprising administering a composition according to claim 1 to a human or animal in need thereof.