Treatment of consumption disorders with biostimulation

• US 8,755,896 B2
• Filed: 02/04/2008
• Issued: 06/17/2014
• Est. Priority Date: 02/05/2007
• Status: Active Grant

• Current Assignee: University of Southern California
• Original Assignee: University of Southern California
• Inventors: Humayun, Mark, Caffey, Sean, Brennan, Jeff
• Primary Examiner(s): Layno, Carl H
• Assistant Examiner(s): GHAND, JENNIFER LEIGH-STEWAR
• Application Number:
  US12/025,454
• Publication Number:
  US 20080221642A1
• Time in Patent Office: 2,325 Days
• Field of Search: 607/2, 607/58, 607/134
• US Class Current: 607/58
• CPC Class Codes: A61N 1/0548 Oral electrodes
• CPC Class Codes: A61N 1/36007 of urogenital or gastrointestinal organs, e.g. for incontinence control
• CPC Class Codes: A61N 1/36025 for treating a mental or cerebral condition

Abstract

Nerves that carry taste sensations to the brain are stimulated in order to diminish (or, depending on the application, augment) the pleasure ordinarily associated with consumption behavior to be modified.

Claims

1. An apparatus for diminishing a user'"'"'s desire for oral gratification, the apparatus comprising:

(a) at least two spaced-apart electrodes for establishing an electric circuit across a portion of a user'"'"'s body, at least one of the electrodes being configured to contact a surface in the user'"'"'s oral cavity; and

(b) circuitry configured to generate, across the electrodes, an electrical signal comprising a train of pulses having a width that is varied over time during a single application of the signal to the surface in the user'"'"'s oral cavity, the signal eliciting a neural response that diminishes the user'"'"'s desire for oral gratification, wherein the train comprises some pulses having a first width and other pulses having a second width different from the first, and the pulse-widths vary from the first width to the second width and back to the first width during a single application of the signal.

2. The apparatus of claim 1, wherein each electrode is constructed of a metal selected from the group consisting of silver, gold, stainless steel, and platinum.

3. The apparatus of claim 1, wherein the signal is biphasic.

4. The apparatus of claim 1, wherein the signal comprises a varying pulse width ranging from 100 μ

sec to 1 msec.

5. The apparatus of claim 4, wherein the pulse width varies over a period of about 4 seconds.

6. The apparatus of claim 1, wherein the signal has a current amplitude ranging from 10 μ

A to 10 mA.

7. The apparatus of claim 1, wherein the electrodes are fabricated from a sterilizable biocompatible material.

8. The apparatus of claim 1, further comprising a monitoring module for monitoring effects of the signal and altering at least one signal characteristic in response to the monitored effects.

9. The apparatus of claim 8, further comprising a memory circuit for retaining data characterizing the altered signal.

10. The apparatus of claim 8, wherein the monitoring module prevents generation of the electrical signal until a resistance or impedance threshold across the electrodes is detected.

11. The apparatus of claim 1, further comprising a housing for supporting at least two electrodes on an external portion thereof, the external portion being configured for insertion into the user'"'"'s oral cavity.

12. The apparatus of claim 1, further comprising ancillary circuitry implementing at least one of an alarm clock, a calendar, an LCD, a camera, an address book, an MP3 player, and a voice note recorder.

13. The apparatus of claim 1, wherein the first width is less than the second width.

14. The apparatus of claim 1, wherein the first width is 100 microseconds and the second width is 1 millisecond.

15. The apparatus of claim 14, wherein the signal has a duration of between 1 and 10 seconds.

16. A method of treating a consumption disorder, the method comprising applying an electrical signal to a surface in a user'"'"'s oral cavity to elicit a neural response that diminishes the user'"'"'s desire for oral gratification, the signal comprising a train of pulses having a width that is varied over time during a single application of the signal to the surface in the user'"'"'s oral cavity, wherein the train comprises some pulses having a first width and other pulses having a second width different from the first, and the pulse-widths vary from the first width to the second width and back to the first width during a single application of the signal.

17. The method of claim 16, wherein the surface is at least one of the hard palate, soft palate, or tongue.

18. The method of claim 16, wherein the signal is biphasic.

19. The method of claim 16, wherein the signal comprises a varying pulse width ranging from 100 μ

sec to 1 msec.

20. The method of claim 19, wherein the pulse width varies over a period of about 4 seconds.

21. The method of claim 16, wherein the signal has a current amplitude ranging from 10 μ

A to 10 mA.

22. The method of claim 16, further comprising the step of adapting the signal to a user.

23. The method of claim 16, wherein the first width is less than the second width.

24. The method of claim 16, wherein the first width is 100 microseconds and the second width is 1 millisecond.