Medical drainage devices with carbon-based structures for inhibiting growth of fibroblasts

• US 8,764,696 B2
• Filed: 06/16/2010
• Issued: 07/01/2014
• Est. Priority Date: 06/16/2009
• Status: Active Grant

• Current Assignee: Mobius Therapeutics, LLC
• Original Assignee: Mobius Therapeutics, Inc.
• Inventors: Lafdi, Khalid, Timm, Edward J.
• Primary Examiner(s): Su, Susan
• Assistant Examiner(s): Townsend, Guy K
• Application Number:
  US12/816,840
• Publication Number:
  US 20110144559A1
• Time in Patent Office: 1,476 Days
• Field of Search: 604/8
• US Class Current: 604/8
• CPC Class Codes: A61F 9/00781 Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment drainage implants in general A61M27/002
• CPC Class Codes: A61L 2400/12 Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
• CPC Class Codes: A61L 29/02 Inorganic materials
• CPC Class Codes: A61L 29/123 having an inorganic matrix
• CPC Class Codes: A61L 29/126 having a macromolecular matrix
• CPC Class Codes: A61L 31/122 of carbon
• CPC Class Codes: A61L 31/125 having a macromolecular matrix
• CPC Class Codes: A61L 31/14 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: A61M 1/3653 Interfaces between patient blood circulation and extra-corporal blood circuit
• CPC Class Codes: A61M 1/3655 Arterio-venous shunts or fistulae
• CPC Class Codes: A61M 1/84 Drainage tubes; Aspiration tips for negative pressure wound therapy A61M1/90; for surgical cutting instruments A61B17/32
• CPC Class Codes: A61M 11/008 by squeezing, e.g. using a flexible bottle or a bulb
• CPC Class Codes: A61M 2025/0037 characterized by lumina being arranged side-by-side
• CPC Class Codes: A61M 2025/006 having a special surface topography or special surface properties, e.g. roughened or knurled surface
• CPC Class Codes: A61M 2210/101 Pleural cavity
• CPC Class Codes: A61M 25/0009 Making of catheters or other medical or surgical tubes
• CPC Class Codes: A61M 25/001 Forming the tip of a catheter, e.g. bevelling process, join or taper
• CPC Class Codes: A61M 25/0012 with embedded structures, e.g. coils, braids, meshes, strands or radiopaque coils
• CPC Class Codes: A61M 25/0026 Multi-lumen catheters with stationary elements catheter assemblies comprising a catheter in combination with a guide tube, sheath or sleeve A61M2025/0681; catheters comprising telescoping coaxial elements A61M2025/0175
• CPC Class Codes: A61M 25/0043 characterised by structural features
• CPC Class Codes: A61M 27/002 : Implant devices for drainage of body fluids from one part of the body to another intraocular A61F9/00781; middle ear A61F11/202
• CPC Class Codes: A61M 27/006 : Cerebrospinal drainage; Accessories therefor, e.g. valves
• CPC Class Codes: B82Y 5/00 : Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
• CPC Class Codes: Y10T 428/1369 : Fiber or fibers wound around each other or into a self-sustaining shape [e.g., yarn, braid, fibers shaped around a core, etc.]
• CPC Class Codes: Y10T 428/23993 : Composition of pile or adhesive

Abstract

Drainage devices for draining a fluid from a patient during treatment of a medical condition body are disclosed. The drainage devices comprise a body defining at least one conduit through the body from a distal end of the body to a proximal end of the body. The body comprises at least one carbon-based structure configured to inhibit growth of fibroblasts in the conduit when the fluid flows through the conduit. Example embodiments of the drainage device may include an ophthalmic shunt, a hydrocephalus shunt, an artificial mesh, an arteriovenous shunt, a thoracic catheter, and a central venous access device.

Claims

1. A drainage device for draining a fluid from a patient during treatment of a medical condition, the drainage device comprising:

a body having inner walls that define at least one conduit through the body from a proximal end of the body to a distal end of the body, the distal end being opposite the proximal end, the body comprising a carbon scaffold comprising carbon fibers optionally combined with a biocompatible polymer; and

a layer of carbon nanotubes grown on the carbon fibers of the body inner walls, the resulting structure forming a carbon fuzzy veil,

wherein;

the carbon fuzzy veil resulting from the carbon nanotubes grown on the carbon scaffold is fibroblast-inhibiting relative to a carbon scaffold alone.

2. The drainage device of claim 1, wherein the carbon fuzzy veil has a ragged microscopic structure.

3. The drainage device of claim 1, wherein the carbon scaffold consists essentially of carbon fibers impregnated with polymethylmethacrylate.

4. The drainage device of claim 1, wherein:

the drainage device is an ophthalmic shunt;

the body is a tubular body having defined therein a proximal opening at the proximal end and a distal opening at the distal end.

5. The drainage device of claim 1, wherein:

the drainage device is an ophthalmic shunt;

the body has defined therein a proximal opening at the proximal end and a distal opening at the distal end; and

the body comprises a plurality of flutes meeting at a central stem, each pair of adjacent flutes defining between the adjacent flutes a separate conduit and a slit in fluid communication with the separate conduit.

6. The drainage device of claim 1, wherein the drainage device is a hydrocephalus shunt and the body is a tubular body defining a closed distal end and a proximal opening, the proximal opening at the proximal end, the tubular body further defining a plurality of openings in fluid communication with the at least one conduit.

7. The drainage device of claim 1, wherein the drainage device is an arteriovenous shunt, and the body further defines a plurality of longitudinal flutes defined along the length of the body and extending from the proximal end to the distal end, each individual longitudinal flute of the plurality of longitudinal flutes having increasing width from the proximal end to the distal end.

8. The drainage device of claim 1, wherein the drainage device is a thoracic catheter and the body has a round cross-section defining a plurality of lumens in communication with multiple longitudinal flutes defined along the entire length of the body, the body further including a terminal point substantially perpendicular to the body and in communication with the plurality of lumens.

9. The drainage device of claim 1, wherein the drainage device is a central venous access device and the body comprises a plurality of lumens and a plurality of longitudinal flutes, the body further defining a proximal opening at the proximal end and a distal opening at the distal end, the proximal opening and the distal opening in fluid communication with the plurality of lumens.

10. The drainage device of claim 1, wherein the carbon scaffold consists essentially of carbon fibers and polymethylmethacrylate, wherein the carbon scaffold is impregnated with polymethylmethacrylate, or the carbon scaffold is built on polymethylmethacrylate or a polymethylmethacrylate substrate.

11. The drainage device of claim 1, wherein the carbon nanotubes cover the inner walls of the device body leaving substantially no uncovered surface.

12. The drainage device of claim 1, wherein the biocompatible polymer is selected from polymethylmethacrylate and polycarbosilane.

13. The drainage device of claim 1, wherein the carbon nanotubes are irregularly distributed over the inner walls of the device body.

14. A drainage device for draining a fluid from a patient during treatment of a medical condition, the drainage device comprising:

a body formed from a flexible composite and having inner walls that define at least one conduit through the body from a proximal end of the body to a distal end of the body, the distal end being opposite the proximal end, the flexible composite comprising a carbon scaffold consisting essentially of carbon fibers combined with a biocompatible polymer; and

a layer of carbon nanotubes grown on the carbon fibers of the body inner walls, the resulting structure forming a carbon fuzzy veil,

wherein;

the carbon fuzzy veil resulting from the carbon nanotubes grown on the carbon scaffold is fibroblast-inhibiting relative to a carbon scaffold alone.

15. The drainage device of claim 14, wherein:

the drainage device is an ophthalmic shunt;

the body is a tubular body having defined therein a proximal opening at the proximal end and a distal opening at the distal end.

16. The drainage device of claim 14, wherein:

the drainage device is an ophthalmic shunt;

the body has defined therein a proximal opening at the proximal end and a distal opening at the distal end; and

the body comprises a plurality of flutes meeting at a central stem, each pair of adjacent flutes defining between the adjacent flutes a separate conduit and a slit in fluid communication with the separate conduit.

17. The drainage device of claim 14, wherein the drainage device is a hydrocephalus shunt and the body is a tubular body defining a closed distal end and a proximal opening, the proximal opening at the proximal end, the tubular body further defining a plurality of openings in fluid communication with the at least one conduit.

18. The drainage device of claim 14, wherein the drainage device is an arteriovenous shunt, and the body further defines a plurality of longitudinal flutes defined along the length of the body and extending from the proximal end to the distal end, each individual longitudinal flute of the plurality of longitudinal flutes having increasing width from the proximal end to the distal end.

19. The drainage device of claim 14, wherein the drainage device is a thoracic catheter and the body has a round cross-section defining a plurality of lumens in communication with multiple longitudinal flutes defined along the entire length of the body, the body further including a terminal point substantially perpendicular to the body and in communication with the plurality of lumens.

20. The drainage device of claim 14, wherein the drainage device is a central venous access device and the body comprises a plurality of lumens and a plurality of longitudinal flutes, the body further defining a proximal opening at the proximal end and a distal opening at the distal end, the proximal opening and the distal opening in fluid communication with the plurality of lumens.

21. The drainage device of claim 14, wherein the carbon fuzzy veil has a ragged microscopic structure.

22. The drainage device of claim 14, wherein the carbon scaffold consists essentially of carbon fibers and polymethylmethacrylate, wherein the carbon scaffold is impregnated with polymethylmethacrylate, or the carbon scaffold is built on polymethylmethacrylate or a polymethylmethacrylate substrate.

23. The drainage device of claim 14, wherein the carbon nanotubes cover the inner walls of the device body leaving substantially no uncovered surface.

24. The drainage device of claim 14, wherein the biocompatible polymer is selected from polymethylmethacrylate and polycarbosilane.

25. The drainage device of claim 14, wherein the carbon nanotubes are irregularly distributed over the inner walls of the device body.