Sheath for use with an ultrasound element

• US 8,764,700 B2
• Filed: 12/20/2011
• Issued: 07/01/2014
• Est. Priority Date: 06/29/1998
• Status: Expired due to Term

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: EKOS Corporation (Boston Scientific Corporation)
• Inventors: Zhang, John, Lichttenegger, Gary, Rodriguey, James E., Tachibana, Katsuro
• Primary Examiner(s): Sirmons, Kevin C
• Assistant Examiner(s): GRAY, PHILLIP A
• Application Number:
  US13/332,226
• Publication Number:
  US 20120089082A1
• Time in Patent Office: 924 Days
• Field of Search: 604 20- 22, 604/96.01, 604/164.01, 604/523, 604/19
• US Class Current: 604/22
• CPC Class Codes: A61B 1/00135 Oversleeves mounted on the endoscope prior to insertion
• CPC Class Codes: A61B 17/22 Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for dilators A61M29/00
• CPC Class Codes: A61B 17/2202 the ultrasound transducer being inside patient's body at the distal end of the catheter
• CPC Class Codes: A61B 2017/22082 after introduction of a substance
• CPC Class Codes: A61B 2017/22084 stone- or thrombus-dissolving
• CPC Class Codes: A61B 2017/320073 probe
• CPC Class Codes: A61B 2017/320084 Irrigation sleeves
• CPC Class Codes: A61B 2018/00011 with fluids
• CPC Class Codes: A61B 8/12 in body cavities or body tracts, e.g. by using catheters catheters per se A61M25/00
• CPC Class Codes: A61M 2025/0057 Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings
• CPC Class Codes: A61M 2025/105 having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
• CPC Class Codes: A61M 25/007 Side holes, e.g. their profiles or arrangements; Provisions to keep side holes unblocked
• CPC Class Codes: A61M 37/0092 using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
• CPC Class Codes: A61M 5/14 Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor

Abstract

An apparatus for delivering ultrasound energy and a drug solution to a treatment site in a vessel is disclosed. The apparatus includes an elongate, hollow sheath having a distal opening and an energy delivery section at least partially constructed from a material that transmits ultrasound energy. The apparatus also includes a drug delivery lumen positioned along at least a portion of the sheath, the drug delivery lumen having at least one drug delivery port within the energy delivery section. The apparatus further includes an elongate body having an ultrasound element, the elongate body configured to be movably positioned within the sheath, such that ultrasonic energy can be transmitted from the ultrasound element through the energy delivery section.

Claims

1. An apparatus for delivering ultrasound energy and a drug solution to a treatment site within a patient'"'"'s vasculature, the apparatus comprising:

an elongate, hollow sheath having a distal opening and an energy delivery section, wherein the sheath within the energy delivery section is at least partially constructed from a material that transmits ultrasound energy;

a drug delivery lumen positioned along at least a portion of the sheath, the drug delivery lumen having a series of drug delivery ports within the energy delivery section, the series of drug delivery ports configured to deliver drug solution to the treatment site;

an elongate body comprising an ultrasound element, the elongate body is movably positioned within the sheath, such that ultrasonic energy can be transmitted from the ultrasound element through the energy delivery section of the sheath; and

a cooling fluid lumen formed between the elongate body and the sheath by positioning the elongate body within the sheath.

2. The apparatus of claim 1, wherein the drug delivery lumen forms a portion of the sheath.

3. The apparatus of claim 1, wherein the energy delivery section comprises a material having low ultrasound absorbance.

4. The apparatus of claim 1, wherein the sheath has an outer surface with a substantially cylindrical cross-sectional profile, and wherein the drug delivery lumen is positioned within the outer surface of the sheath.

5. The apparatus of claim 1, wherein the elongate body comprises a plurality of ultrasound elements.

6. The apparatus of claim 1, further comprising a cooling fluid lumen defined by a region of the sheath not occupied by the elongate body.

7. The apparatus of claim 1, wherein the cooling fluid lumen is adjacent to the drug delivery lumen and the elongate body.

8. The apparatus of claim 1, wherein a first portion of the drug delivery lumen, located outside the energy delivery section, is not perforated, and wherein a second portion of the drug delivery lumen, located within the energy delivery section, is perforated.

9. The apparatus of claim 1, wherein a plurality of drug delivery lumens are positioned along at least a portion of the sheath.

27. The apparatus of claim 1, wherein a first portion of the drug delivery lumen located within the energy delivery section is external to the sheath.

28. The apparatus of claim 27, wherein a second portion of the drug delivery lumen located outside the energy delivery section is incorporated into the sheath.

29. The apparatus of claim 27, wherein a second portion of the drug delivery lumen located outside the energy delivery section is external to the sheath.

30. The apparatus of claim 1, wherein the series of drug delivery ports have different sizes.

31. The apparatus of claim 1, wherein the drug delivery lumen is wound around the energy delivery section.

32. The apparatus of claim 1, wherein the density of the series of drug delivery ports changes along the length of the energy delivery section.

33. The apparatus of claim 1, wherein the series of drug delivery ports are slits.

10. An apparatus comprising:

an elongate, hollow utility lumen having a proximal region and distal region opposite the proximal region, wherein the utility lumen comprises a drug delivery lumen that extends from the proximal region to the distal region, and the drug delivery lumen comprises a plurality of drug delivery ports in the distal region; and

an elongate body comprising an ultrasound element, the elongate body is movably inserted within the utility lumen, such that the ultrasound element is positionable within the distal region of the utility lumen, and

a cooling fluid lumen defined by a region of the utility lumen not occupied by the elongate body.

11. The apparatus of claim 10, wherein at least a portion of the utility lumen distal region comprises a material having low ultrasound absorbance.

12. The apparatus of claim 10, wherein the utility lumen distal region has an outer surface with a substantially cylindrical cross-sectional profile, and wherein the drug delivery lumen is positioned within the outer surface of the utility lumen.

13. The apparatus of claim 10, wherein the elongate body comprises a plurality of ultrasound elements.

14. The apparatus of claim 10, wherein a cooling fluid lumen is form between the elongate body and the utility lumen by insertion of the elongate body into the utility lumen.

15. The apparatus of claim 10, wherein the cooling fluid lumen is adjacent to the drug delivery lumen and the elongate body.

16. The apparatus of claim 10, wherein a first portion of the drug delivery lumen, located in the proximal region of the utility lumen, is not perforated, and wherein a second portion of the drug delivery lumen, located in the distal region of the utility lumen, is perforated.

17. The apparatus of claim 10, wherein the utility lumen includes a plurality of perforated drug delivery lumens.

18. A system for delivering ultrasound energy and a drug solution to a treatment site within a patient'"'"'s vasculature, the system comprising:

an elongate sheath configured to be inserted into the patient'"'"'s vasculature, the elongate sheath forming a utility lumen having an energy delivery section;

a drug delivery lumen positioned along the elongate sheath, the drug delivery lumen having a plurality of perforations along the energy delivery section, such that a drug solution can be delivered into the patient'"'"'s vasculature in a treatment site adjacent the energy delivery section; and

an elongate body having an ultrasound element, wherein the elongate body is insertable and movable within, the utility lumen, such that a cooling fluid lumen is formed between the elongate body and the utility lumen.

19. The system of claim 18, wherein the drug delivery lumen forms a portion of the sheath.

20. The system of claim 18, wherein the energy delivery section comprises a material having low ultrasound absorbance.

21. The system of claim 18, wherein the drug delivery lumen is positioned within the utility lumen.

22. The system of claim 18, wherein the elongate body includes a plurality of ultrasound elements.

23. The system of claim 18, wherein insertion of the elongate body into the utility lumen forms a cooling fluid lumen defined by a region of the utility lumen not occupied by the elongate body.

24. The system of claim 18, wherein insertion of the elongate body into the utility lumen forms a cooling fluid lumen adjacent to the drug delivery lumen and the elongate body.

25. The system of claim 18, wherein a first portion of the drug delivery lumen, located outside the energy delivery section, is not perforated, and wherein a second portion of the drug delivery lumen, located within the energy delivery section, is perforated.

26. The system of claim 18, wherein a plurality of drug delivery lumens are positioned along the elongate sheath.