Systems and methods of discriminating control solution from a physiological sample
First Claim
1. A method for distinguishing between a blood sample and an aqueous non-blood sample, the method comprising:
- (a) applying a first test potential between a first electrode and a second electrode when a sample is introduced into an electrochemical cell and measuring a first current transient;
(b) applying a second test potential between a first electrode and a second electrode, the second test potential being sufficient to oxidize a reduced mediator at the second electrode and measuring a second current transient;
(c) applying a third test potential between a first electrode and a second electrode, the third test potential being sufficient to oxidize a reduced mediator at the first electrode, and measuring a third current transient;
(d) calculating, based upon a summation of three or more current values measured during the first current transient, a first reference value;
(e) calculating, based on the second and third current transients, a second reference value; and
(f) determining, based on the first and second reference values, whether the sample is a blood sample or an aqueous non-blood sample.
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Abstract
Methods for distinguishing between an aqueous non-blood sample (e.g., a control solution) and a blood sample are provided herein. In one aspect, the method includes using a test strip in which multiple current transients are measured by a meter electrically connected to an electrochemical test strip. The current transients are used to determine if a sample is a blood sample or an aqueous non-blood sample based on at least two characteristics (e.g., amount of interferent present and reaction kinetics). The method can also include calculating a discrimination criteria based upon at least two characteristics. Various aspects of a system for distinguishing between a blood sample and an aqueous non-blood sample are also provided herein.
184 Citations
16 Claims
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1. A method for distinguishing between a blood sample and an aqueous non-blood sample, the method comprising:
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(a) applying a first test potential between a first electrode and a second electrode when a sample is introduced into an electrochemical cell and measuring a first current transient; (b) applying a second test potential between a first electrode and a second electrode, the second test potential being sufficient to oxidize a reduced mediator at the second electrode and measuring a second current transient; (c) applying a third test potential between a first electrode and a second electrode, the third test potential being sufficient to oxidize a reduced mediator at the first electrode, and measuring a third current transient; (d) calculating, based upon a summation of three or more current values measured during the first current transient, a first reference value; (e) calculating, based on the second and third current transients, a second reference value; and (f) determining, based on the first and second reference values, whether the sample is a blood sample or an aqueous non-blood sample. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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Specification