Monoclonal antibodies to programmed death 1 (PD-1)

  • US 8,779,105 B2
  • Filed: 08/15/2011
  • Issued: 07/15/2014
  • Est. Priority Date: 05/09/2005
  • Status: Active Grant
First Claim
Patent Images

1. A monoclonal antibody or an antigen-binding portion thereof, which cross-competes for binding to PD-1 with a reference antibody or antigen-binding portion thereof that comprises:

  • (a) a heavy chain variable region comprising amino acids having the sequence set forth in SEQ ID NO;

    1 and a light chain variable region comprising amino acids having the sequence set forth in SEQ ID NO;

    8;

    (b) a heavy chain variable region comprising amino acids having the sequence set forth in SEQ ID NO;

    2 and a light chain variable region comprising amino acids having the sequence set forth in SEQ ID NO;

    9;

    (c) a heavy chain variable region comprising amino acids having the sequence set forth in SEQ ID NO;

    3 and a light chain variable region comprising amino acids having the sequence set forth in SEQ ID NO;

    10;

    (d) a heavy chain variable region comprising amino acids having the sequence set forth in SEQ ID NO;

    4 and a light chain variable region comprising amino acids having the sequence set forth in SEQ ID NO;

    11;

    (e) a heavy chain variable region comprising amino acids having the sequence set forth in SEQ ID NO;

    5 and a light chain variable region comprising amino acids having the sequence set forth in SEQ ID NO;

    12;

    (f) a heavy chain variable region comprising amino acids having the sequence set forth in SEQ ID NO;

    6 and a light chain variable region comprising amino acids having the sequence set forth in SEQ ID NO;

    13;

    or(g) a heavy chain variable region comprising amino acids having the sequence set forth in SEQ ID NO;

    7 and a light chain variable region comprising amino acids having the sequence set forth in SEQ ID NO;

    14.

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