Photoacoustic spectroscopy method and system to discern sepsis from shock
First Claim
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1. A method of monitoring a patient, comprising:
- using a processor to perform the steps of;
controlling a driver of a light source of a photoacoustic spectroscopy sensor, wherein the light source is configured to emit one or more wavelengths of light;
receiving a signal from the photoacoustic spectroscopy sensor, wherein the signal is representative of a microcirculatory parameter of a patient;
calculating the microcirculatory parameter based at least in part on the signal via one or more algorithms stored in a memory;
determining whether the patient has shock or sepsis based at least in part on the microcirculatory parameter, wherein determining if the patient has sepsis comprises monitoring the microcirculatory parameter over a period of time and determining if a decrease in the microcirculatory parameter is not followed by a rise in the microcirculatory parameter; and
providing an indication of the microcirculatory parameter on a display.
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Abstract
According to various embodiments, a medical system and method for determining a microcirculation parameter of a patient may include a photoacoustic sensor. Specifically, a signal from a photoacoustic sensor may be used to determine if a patient is likely to have sepsis or shock. Although sepsis and shock present similarly with regard to many patient parameters, they may be differentiated by characteristic microcirculation changes.
236 Citations
16 Claims
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1. A method of monitoring a patient, comprising:
- using a processor to perform the steps of;
controlling a driver of a light source of a photoacoustic spectroscopy sensor, wherein the light source is configured to emit one or more wavelengths of light;
receiving a signal from the photoacoustic spectroscopy sensor, wherein the signal is representative of a microcirculatory parameter of a patient;
calculating the microcirculatory parameter based at least in part on the signal via one or more algorithms stored in a memory;
determining whether the patient has shock or sepsis based at least in part on the microcirculatory parameter, wherein determining if the patient has sepsis comprises monitoring the microcirculatory parameter over a period of time and determining if a decrease in the microcirculatory parameter is not followed by a rise in the microcirculatory parameter; and
providing an indication of the microcirculatory parameter on a display. - View Dependent Claims (2, 3, 4, 5, 6)
- using a processor to perform the steps of;
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7. A method of monitoring a patient, comprising:
- using a processor;
receiving a first signal from a first sensor related to a clinical parameter, wherein the clinical parameter is one or more of a patient'"'"'s blood pressure, a heart rate, a cardiac output, blood constituents, a respiration rate, a respiration effort, or a temperature;
determining if the first signal is associated with a possible sepsis or a possible shock condition;
activating a photoacoustic sensor if the first signal is associated with the possible sepsis or the possible shock condition, wherein activating the photoacoustic sensor comprises providing instructions to drive a light emitter of the photoacoustic sensor;
receiving a second signal from the photoacoustic sensor related to one or more microcirculatory parameters of the patient;
calculating a microcirculatory parameter of the patient based on the second signal; and
distinguishing between sepsis or shock based at least in part on the determined microcirculatory parameter, wherein the distinguishing comprises;
determining that the patient has shock based on a decrease in the microcirculatory parameter followed by a rise in the microcirculatory parameter; and
determining that the patient has sepsis based on a decrease in the microcirculatory parameter not followed by a rise in the microcirculatory parameter. - View Dependent Claims (8, 9, 11, 12, 13, 14, 15, 16)
- using a processor;
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10. A method of monitoring a patient, comprising:
using a processor to perform the steps of; controlling a driver of a light emitter of a first sensor; receiving a first signal from the first sensor related to a clinical parameter, wherein the clinical parameter is associated with a possible sepsis or a possible shock condition; activating a driver of a light source of a photoacoustic spectroscopy sensor based on an increase or decrease in the clinical parameter, wherein the light source is configured to emit one or more wavelengths of light; receiving a second signal from an acoustic detector of the photoacoustic spectroscopy sensor, wherein the second signal is representative of a blood flow parameter of a patient; determining the blood flow parameter based at least in part on the second signal; determining whether the patient has shock or sepsis based at least in part on the blood flow parameter, wherein determining if the patient has shock comprises monitoring the blood flow parameter over a period of time and determining if a decrease in the blood flow parameter is followed by a rise in the blood flow parameter; and providing an indication of the blood flow parameter over the period of time on a display, comprising providing a indication of shock if the patient has shock and an indication of sepsis if the patient has sepsis.
Specification