Glaucoma drainage device with pump

• US 8,808,224 B2
• Filed: 03/27/2013
• Issued: 08/19/2014
• Est. Priority Date: 09/21/2009
• Status: Active Grant

• Current Assignee: Alcon Incorporated
• Original Assignee: Alcon Research Limited (Nestle SA)
• Inventors: Rickard, Matthew J. A.
• Primary Examiner(s): Zalukaeva, Tatyana
• Assistant Examiner(s): KLEIN, BENJAMIN JACOB
• Application Number:
  US13/851,533
• Publication Number:
  US 20130218064A1
• Time in Patent Office: 510 Days
• Field of Search: 604/8, 604/9
• US Class Current: 604/9
• CPC Class Codes: A61F 9/00781 Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment drainage implants in general A61M27/002
• CPC Class Codes: A61P 27/06 Antiglaucoma agents or miotics

Abstract

A glaucoma drainage device has a main drainage tube with a first end an anterior chamber of an eye and a second end in a drainage location. A bypass drainage tube is fluidly coupled to and in parallel with the main drainage tube. A pump is in communication with the bypass drainage tube. The pump comprises a first driver and a first flexible membrane enclosing a first chamber. A first check valve is located upstream from the pump, and a second check valve is located downstream from the pump. An active valve is located upstream from the first check valve. The active valve comprises a second driver and a second flexible membrane enclosing a second chamber. A third check valve is located between the active valve and the second end of the main drainage tube. A volume of the first chamber is changed to pump fluid from the anterior chamber.

Claims

1. A glaucoma drainage device comprising:

a tube with a first end configured to be located in an anterior chamber of an eye and a second end configured to be located in a drainage location;

a pump in communication with the tube, the pump comprising a driver and a flexible membrane enclosing a chamber;

a first check valve located upstream of the pump;

a second check valve located downstream of the pump;

a first pressure sensor located in fluid communication with the anterior chamber of the eye;

a second pressure sensor located remotely from the first pressure sensor; and

a third pressure sensor located in the drainage location;

wherein a volume of the chamber is changed to pump fluid from the anterior chamber to the drainage location; and

further wherein the tube, the pump, the first check valve, the second check valve, the first pressure sensor, the second pressure sensor, and the third pressure sensor are all located on a single implant.

2. The glaucoma drainage device of claim 1 wherein the chamber contains water and the driver is configured to perform electrolysis of the water.

3. The glaucoma drainage device of claim 2 wherein the driver comprises a pair of electrodes in contact with the water.

4. The glaucoma drainage device of claim 1 wherein the drainage location is selected from the group consisting of:

a subconjunctival space, a suprachoroidal space, a subscleral space, a supraciliary space, Schlemm'"'"'s canal, a collector channel, an episcleral vein, and a uveo-scleral pathway.

5. The glaucoma drainage device of claim 1 further comprising:

a power source coupled to the driver.

6. The glaucoma drainage device of claim 1 wherein a difference between readings from the first pressure sensor and the third pressure sensor approximates a pressure differential between the anterior chamber and the drainage location.

7. The glaucoma drainage device of claim 6 wherein readings from the first pressure sensor and the third pressure sensor are used to control the pump.

8. The glaucoma drainage device of claim 1 wherein the second pressure sensor measures or approximates atmospheric pressure;

and a difference between readings from the first pressure sensor and the second pressure sensor approximates intraocular pressure.

9. The glaucoma drainage device of claim 8 wherein the second pressure sensor is located in a subconjunctival space of the eye.

10. The glaucoma drainage device of claim 8 wherein readings from the first pressure sensor and the second pressure sensor are used to control the pump.

11. A glaucoma drainage device comprising:

a main drainage tube with a first end configured to be located in an anterior chamber of an eye and a second end configured to be located in a drainage location;

a bypass drainage tube fluidly coupled to and in parallel with the main drainage tube;

a pump in communication with the bypass drainage tube, the pump comprising a first driver and a first flexible membrane enclosing a first chamber;

a first check valve located upstream of the pump;

a second check valve located downstream of the pump;

an active valve located upstream of the first check valve, the active valve comprising a second driver and a second flexible membrane enclosing a second chamber;

a third check valve located between the active valve and the second end of the main drainage tube;

a first pressure sensor located in fluid communication with the anterior chamber of the eye;

a second pressure sensor located remotely from the first pressure sensor; and

a third pressure sensor located in the drainage location;

wherein a volume of the first chamber is changed to pump fluid from the anterior chamber to the drainage location; and

further wherein the main tube, the bypass tube, the pump, the first check valve, the second check valve, the active valve, the first pressure sensor, the second pressure sensor, and the third pressure sensor are all located on a single implant.

12. The glaucoma drainage device of claim 11 wherein the first or second chamber contains water and the first or second driver is configured to perform electrolysis of the water.

13. The glaucoma drainage device of claim 12 wherein the first or second driver comprises a pair of electrodes in contact with the water.

14. The glaucoma drainage device of claim 11 wherein the drainage location is selected from the group consisting of:

a subconjunctival space, a suprachoroidal space, a subscleral space, a supraciliary space, Schlemm'"'"'s canal, a collector channel, an episcleral vein, and a uveo-scleral pathway.

15. The glaucoma drainage device of claim 11 further comprising:

a power source coupled to the first and second drivers.

16. The glaucoma drainage device of claim 11 wherein a difference between readings from the first pressure sensor and the third pressure sensor approximates a pressure differential between the anterior chamber and the drainage location.

17. The glaucoma drainage device of claim 16 wherein readings from the first pressure sensor and the third pressure sensor are used to control the pump or the active valve.

18. The glaucoma drainage device of claim 11 wherein the second pressure sensor measures or approximates atmospheric pressure;

and a difference between readings from the first pressure sensor and the second pressure sensor approximates intraocular pressure.

19. The glaucoma drainage device of claim 18 wherein the second pressure sensor is located in a subconjunctival space of the eye.

20. The glaucoma drainage device of claim 18 wherein readings from the first pressure sensor and the second pressure sensor are used to control the pump or the active valve.

21. The glaucoma drainage device of claim 11 wherein a volume of the second chamber is changed to at least partially occlude the main drainage tube.

22. A glaucoma drainage device comprising:

a drainage tube with a first end configured to be located in an anterior chamber of an eye and a second end configured to be located in a drainage location;

an active valve in communication with the drainage tube, the active valve comprising a driver and a flexible membrane enclosing a chamber;

a check valve located between the active valve and the second end of the main drainage tube;

a first pressure sensor located in fluid communication with the anterior chamber of the eye;

a second pressure sensor located remotely from the first pressure sensor; and

a third pressure sensor located in the drainage location;

wherein a volume of the chamber is changed to at least partially occlude the drainage tube; and

further wherein the drainage tube, the active valve, the check valve, the first pressure sensor, and the remote pressure sensor are all located on a single implant.

23. The glaucoma drainage device of claim 22 wherein the chamber contains water and the driver is configured to perform electrolysis of the water.

24. The glaucoma drainage device of claim 22 wherein the drainage location is selected from the group consisting of:

a subconjunctival space, a suprachoroidal space, a subscleral space, a supraciliary space, Schlemm'"'"'s canal, a collector channel, an episcleral vein, and a uveo-scleral pathway.

25. The glaucoma drainage device of claim 22 further comprising:

a power source coupled to the driver.

26. The glaucoma drainage device of claim 22 wherein a difference between readings from the first pressure sensor and the third pressure sensor approximates a pressure differential between the anterior chamber and the drainage location.

27. The glaucoma drainage device of claim 26 wherein readings from the first pressure sensor and the third pressure sensor are used to control the active valve.

28. The glaucoma drainage device of claim 22 wherein the second pressure sensor measures or approximates atmospheric pressure;

and a difference between readings from the first pressure sensor and the second pressure sensor approximates intraocular pressure.

29. The glaucoma drainage device of claim 28 wherein the second pressure sensor is located in a subconjunctival space of the eye.

30. The glaucoma drainage device of claim 28 wherein readings from the first pressure sensor and the second pressure sensor are used to control the active valve.