Encased tamper resistant controlled release dosage forms

  • US 8,808,740 B2
  • Filed: 12/21/2011
  • Issued: 08/19/2014
  • Est. Priority Date: 12/22/2010
  • Status: Active Grant
First Claim
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1. A solid controlled release dosage form comprising:

  • a core comprising a first portion of an opioid analgesic dispersed in a first controlled release matrix material; and

    a shell encasing the core and comprising a second portion of the opioid analgesic dispersed in a second controlled release matrix material;

    wherein the amount of opioid analgesic released from the dosage form is proportional within 20% to elapsed time from 8 to 24 hours, as measured by an in-vitro dissolution in a USP Apparatus 1 (basket) at 100 rpm in 900 ml simulated gastric fluid without enzymes (SGF) at 37°

    C.

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