Inhibitor which is deactivatable by a reagent produced by a target cell

  • US 8,809,504 B2
  • Filed: 08/30/2003
  • Issued: 08/19/2014
  • Est. Priority Date: 09/03/2002
  • Status: Active Grant
First Claim
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1. An inhibitor which is deactivatable by a reagent produced by a target cell comprising:

  • (a) a first moiety that binds, inhibits, suppresses, neutralizes, or decreases activity of a biologically active agent wherein said first moiety is operably linked to;

    (b) a second moiety specifically cleavable by a protease produced by a target cell, wherein said first and second moieties are not attached in nature and wherein specific cleavage of said second moiety causes reduction of binding activity of said inhibitor.

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