Devices and methods for performing medical procedures in tree-like luminal structures

• US 8,821,376 B2
• Filed: 03/12/2008
• Issued: 09/02/2014
• Est. Priority Date: 03/12/2007
• Status: Active Grant

• Current Assignee: David Tolkowsky
• Original Assignee: David Tolkowsky
• Inventors: Tolkowsky, David
• Primary Examiner(s): Leubecker, John P
• Assistant Examiner(s): TORRES DIAZ, ARNALDO
• Application Number:
  US12/527,508
• Publication Number:
  US 20100041949A1
• Time in Patent Office: 2,365 Days
• Field of Search: 600/104, 600116-117, 600/127, 600/156, 600/414, 600/415, 600424-427, 600/435, 600/106, 600/109, 606/108, 128/207.16
• US Class Current: 600/104
• CPC Class Codes: A61B 1/0052 Constructional details of control elements, e.g. handles
• CPC Class Codes: A61B 1/018 for receiving instruments
• CPC Class Codes: A61B 1/2676 Bronchoscopes
• CPC Class Codes: A61B 17/00491 Surgical glue applicators surgical adhesives A61L24/00; two-component delivery syringes A61M5/19
• CPC Class Codes: A61B 17/12104 in an air passage
• CPC Class Codes: A61B 17/12159 Solid plugs; being solid before insertion
• CPC Class Codes: A61B 2017/1205 Introduction devices
• CPC Class Codes: A61B 2034/105 Modelling of the patient, e.g. for ligaments or bones
• CPC Class Codes: A61B 2034/2051 Electromagnetic tracking systems
• CPC Class Codes: A61B 2090/364 Correlation of different images or relation of image positions in respect to the body
• CPC Class Codes: A61B 2090/365 augmented reality, i.e. correlating a live optical image with another image
• CPC Class Codes: A61B 2090/3735 Optical coherence tomography [OCT]
• CPC Class Codes: A61B 2090/378 using ultrasound
• CPC Class Codes: A61B 34/20 Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
• CPC Class Codes: A61B 5/064 using markers A61B5/062 takes precedence
• CPC Class Codes: A61B 5/066 Superposing sensor position on an image of the patient, e.g. obtained by ultrasound or x-ray imaging
• CPC Class Codes: A61B 5/7285 for synchronising or triggering a physiological measurement or image acquisition with a physiological event or waveform, e.g. an ECG signal A61B6/5205, A61B6/541, A61B8/5207, A61B8/543 take precedence
• CPC Class Codes: A61B 5/742 using visual displays A61B5/339 takes precedence
• CPC Class Codes: A61B 6/03 Computed tomography [CT] echo-tomography A61B8/14
• CPC Class Codes: A61B 6/466 adapted to display 3D data
• CPC Class Codes: A61B 6/5247 : combining images from an ionising-radiation diagnostic technique and a non-ionising radiation diagnostic technique, e.g. X-ray and ultrasound
• CPC Class Codes: A61B 6/541 : involving acquisition triggered by a physiological signal
• CPC Class Codes: A61B 8/12 : in body cavities or body tracts, e.g. by using catheters catheters per se A61M25/00
• CPC Class Codes: A61B 8/4254 : using sensors mounted on the probe
• CPC Class Codes: A61B 8/5238 : for combining image data of patient, e.g. merging several images from different acquisition modes into one image for image registration algorithms G06T7/30
• CPC Class Codes: A61B 8/543 : involving acquisition triggered by a physiological signal
• CPC Class Codes: A61B 90/36 : Image-producing devices or illumination devices not otherwise provided for
• CPC Class Codes: A61B 90/361 : Image-producing devices, e.g. surgical cameras

Abstract

Apparatus is described for use with an imaging device (31) that acquires a pre-procedure image of a portion of a subject'"'"'s body disposed at a pre-procedure position. An input unit receives from a user an indication of two or more lines within the image that correspond to respective branches of a multi-branch luminal structure. A probe (1) moves within the portion along two or more lines in the structure that respectively correspond to the two or more lines within the image. A location sensor (18) coupled to the probe senses location coordinates along the two or more lines, while the portion is at a current position. A control unit (34) registers the image of the portion with the portion'"'"'s current position by registering (a) the two or more lines within the image, with (b) the location coordinates along the two or more lines. Other embodiments are also described.

Claims

1. Apparatus for suctioning trapped fluid from one or more bullae situated in an emphysematous lung region of a subject, the apparatus comprising:

a plug configured to be placed in an airway of the subject, the airway leading to the emphysematous lung region, the plug defining an opening therethrough that is in an open state thereof when something is inserted through the opening and is in a closed state thereof when nothing is inserted through the opening;

a tool having a distal portion and a proximal portion that is proximal to the distal portion, the tool being configured to facilitate suctioning therethrough of the fluid trapped within the one or more bullae of the region, while the proximal portion of the tool is disposed within the opening through the plug; and

a navigation aid configured to facilitate suctioning through the tool of the fluid trapped within the one or more bullae of the emphysematous region, by, prior to suctioning through the tool being applied, facilitating navigation of the distal portion of the tool to respective individual bullae of the region,

the navigation aid comprising at least one navigation aid selected from the group consisting of;

an intra-operative, endoluminal imaging probe configured to be inserted by means of the tool and to verify the location of the tool with respect to the individual bullae by acquiring endoluminal images from within the emphysematous lung region, and

an image-guided navigation system that comprises a location sensor coupled to the distal portion of the tool, the navigation system being configured (a) using the location sensor, to sense a current location of the distal portion of the tool when the distal portion of the tool is within the emphysematous lung region, and (b) in response thereto, to generate an indication of the current location of the distal portion of the tool on a previously-acquired image of a portion of the subject'"'"'s body that contains the emphysematous lung region.

2. The apparatus according to claim 1,

wherein the navigation aid comprises the endoluminal imaging probe, the endoluminal imaging probe being configured to verify the location of the tool with respect to the individual bullae.

3. The apparatus according to claim 2, wherein the tool comprises a sheath, the apparatus further comprising a second tool configured to be inserted through the sheath.

4. The apparatus according to claim 2, wherein the imaging probe is insertable through the tool.

5. The apparatus according to claim 1, wherein the navigation aid comprises the image-guided navigation system.

6. The apparatus according to claim 5, wherein the tool comprises a sheath and wherein the location sensor is attached to the sheath.

7. The apparatus according to claim 6, further comprising a tool configured to be inserted through the sheath.

8. The apparatus according to claim 5, further comprising a sheath, wherein the tool is configured to be inserted through the sheath.

9. The apparatus according to claim 8, wherein the location sensor is attached to the distal portion of the tool.

10. The apparatus according to claim 8, wherein the location sensor is coupled to the distal portion of the tool via the sheath.

11. The apparatus according to claim 10, wherein the location sensor is attached to the sheath.

12. The apparatus according to claim 5, wherein the image-guided navigation system comprises a control unit configured to generate the indication of the current location of the distal portion of the tool on the previously-acquired image of the portion of the subject'"'"'s body by:

registering the previously-acquired image of the portion of the subject'"'"'s body with a current position of the portion of the subject'"'"'s body, and

generating the indication of the current location of the distal portion of the tool at a location within the registered image that corresponds to the sensed location of the distal portion of the tool.

13. The apparatus according to claim 5, further comprising an intra-operative, endoluminal imaging probe configured to verify the location of the tool with respect to the individual bullae by acquiring endoluminal images from within the emphysematous lung region.

14. The apparatus according to claim 1, further comprising an endoscope configured to be inserted into the airway, the endoscope being unable to be inserted through the opening, wherein the tool is configured to be inserted through the opening by protruding from a distal end of the endoscope.

15. The apparatus according to claim 1, wherein the tool is configured to suction fluid from within at least one of the individual bullae a plurality of times.

16. The apparatus according to claim 1, wherein the navigation aid is configured to successively facilitate navigation of the distal portion of the tool to a plurality of individual bullae within the emphysematous region, and the tool is configured to successively facilitate suctioning therethrough of fluid from within each of the plurality of individual bullae.

17. A method for suctioning trapped fluid from one or more bullae situated in an emphysematous lung region of a subject, the method comprising:

inserting a plug into an airway of the subject, the airway leading to the emphysematous lung region, the plug defining an opening therethrough that is in an open state thereof when something is inserted through the opening and is in a closed state thereof when nothing is inserted through the opening;

directing toward respective individual bullae of the region, a distal portion of a tool, the tool having a distal portion and a proximal portion that is proximal to the distal portion, the directing of the distal portion of the tool toward the bullae being performed by;

determining a location of the tool with respect to the respective individual bullae of the region; and

directing the distal portion of the tool to the respective individual bullae of the region, in response to the determined location of the tool; and

suctioning the fluid through the tool from within the respective individual bullae of the region, while the proximal portion of tool is disposed within the opening through the plug, and subsequent to the directing of the distal portion of the tool to the respective individual bullae of the region.

18. The method according to claim 17, wherein

determining the location of the tool with respect to respective individual bullae of the region comprises acquiring images from within the emphysematous lung region using an endoluminal imaging probe.

19. The method according to claim 17, wherein suctioning the fluid through the tool, subsequent to the directing of the distal portion of the tool to the respective individual bullae of the region, comprises using weaker suction to suction the fluid than would be used if the tool was not directed to the respective individual bullae of the region.

20. The method according to claim 17, wherein:

determining the location of the tool with respect to respective individual bullae of the region comprises;

providing a previously-acquired image of a portion of the subject'"'"'s body that includes at least some of the region;

generating an indication of a location of the distal portion of the tool within the previously-acquired image, by sensing the location of the distal portion of the tool; and

directing the distal portion of the tool to the respective individual bullae of the region comprises directing the distal portion of the tool to the respective individual bullae of the region using the indication of the location of the distal portion within the previously-acquired image.

21. The method according to claim 20, wherein directing the distal portion of the tool toward respective individual bullae comprises inserting the tool through the airway via a sheath.

22. The method according to claim 20, wherein generating the indication of the location of the distal portion of the tool within the previously-acquired image comprises:

registering the previously-acquired image of the portion of the subject'"'"'s body with a current position of the portion of the subject'"'"'s body; and

generating an indication of the distal portion of the tool at a location within the registered image that corresponds to the sensed location of the distal portion of the tool.

23. The method according to claim 20, further comprising

facilitating verification of the location of the tool with respect to the respective individual bullae by endoluminal imaging.

24. The method according to claim 17,

further comprising inserting an endoscope into the airway,

wherein directing the distal portion of the tool toward respective individual bullae comprises advancing the tool via the endoscope, beyond a distal end of the endoscope, and

wherein the method does not comprise inserting the endoscope through the opening.

25. The method according to claim 17, wherein suctioning the fluid comprises suctioning fluid from within at least one of the respective individual bullae a plurality of times.

26. The method according to claim 25, wherein suctioning fluid from within at least one of the respective individual bullae the plurality of times comprises:

suctioning fluid from within the respective individual bullae a first time; and

suctioning fluid from within at least one of the respective individual bullae a second time, subsequent to further fluid having accumulated within the emphysematous lung region, after having suctioned fluid from within each of the respective individual bullae for the first time.

27. The method according to claim 17, wherein inserting the tool comprises inserting a sheath, the method further comprising inserting a second tool through the sheath.

28. The method according to claim 17, wherein directing the distal portion of the tool to the respective individual bullae of the region comprises successively directing the distal portion of the tool to a plurality of individual bullae of the region, and wherein suctioning the fluid through the tool from within the individual bullae of the region comprises successively suctioning fluid through the tool from within each of the plurality of individual bullae.

29. The method according to claim 17, wherein the tool includes an endoscopy tool, and wherein directing the tool toward the respective individual bullae comprises directing the endoscopy tool toward the respective individual bullae.