Adjuvanting meningococcal factor H binding protein

  • US 8,834,888 B2
  • Filed: 02/14/2013
  • Issued: 09/16/2014
  • Est. Priority Date: 03/24/2009
  • Status: Active Grant
First Claim
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1. An immunogenic composition comprising two different meningococcal factor H binding protein (fHBP) antigens, both of which are adsorbed to aluminium hydroxyphosphate adjuvant, wherein (i) both of the meningococcal fHBP antigens have an isoelectric point between 5.0 and 7.0, and (ii) the aluminium hydroxyphosphate adjuvant has a point of zero charge between 5.0 and 7.0, wherein at least 85% of the each of the fHBP antigens is adsorbed to the aluminium hydroxyphosphate adjuvant.

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