Multilayer membrane actuators

• US 8,840,578 B2
• Filed: 12/09/2011
• Issued: 09/23/2014
• Est. Priority Date: 12/09/2011
• Status: Active Grant

• Current Assignee: Alcon Research, LLC (Alcon Incorporated)
• Original Assignee: Alcon Research Limited (Nestle SA)
• Inventors: Dos Santos, Cesario P., Gelvin, Michael L.
• Primary Examiner(s): MARCETICH, ADAM M
• Application Number:
  US13/315,905
• Publication Number:
  US 20130150775A1
• Time in Patent Office: 1,019 Days
• Field of Search: 604/890.1, 604/891.1, 604/892.1, 623/4.1, 623/5.11, 623/23.64
• US Class Current: 604/9
• CPC Class Codes: A61F 2210/0076 multilayered, e.g. laminated structures
• CPC Class Codes: A61F 9/0017 implantable in, or in contact with, the eye, e.g. ocular inserts
• CPC Class Codes: A61F 9/007 Methods or devices for eye surgery
• CPC Class Codes: A61F 9/00781 Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment drainage implants in general A61M27/002
• CPC Class Codes: A61M 2005/14204 with gas-producing electrochemical cell
• CPC Class Codes: A61M 2005/14513 with secondary fluid driving or regulating the infusion
• CPC Class Codes: A61M 2202/0014 removed from the body
• CPC Class Codes: A61M 2202/04 Liquids
• CPC Class Codes: A61M 2205/8231 using electrochemical gas generating device for the driving gas
• CPC Class Codes: A61M 2210/0612 Eyes
• CPC Class Codes: A61M 27/002 Implant devices for drainage of body fluids from one part of the body to another intraocular A61F9/00781; middle ear A61F11/202
• CPC Class Codes: A61M 5/14276 specially adapted for implantation

Abstract

An IOP control device for implantation in an eye of a patient is disclosed. The device includes a housing and a multilayer membrane. The housing is sized for implantation into the eye and includes an entrance port and an exit port. The membrane is anchored within the housing to form a flow control chamber on a first side and a fluid flow passageway on a second opposing side of the membrane. The chamber is arranged to contain a gas creating a chamber pressure, and the membrane is configured to affect flow through the passageway from the entrance port to the exit port by deflecting in response to changes in the chamber pressure. The membrane comprises a first layer having a higher permeability and a higher flexibility than the second layer, which is disposed adjacent the first layer and restricts the diffusion of gas in the chamber through the membrane.

Claims

1. An IOP control device for implantation in an eye of a patient, comprising:

a housing sized for implantation into the eye of the patient and including an entrance port and an exit port; and

a multilayer membrane anchored within the housing in a manner forming a flow control chamber on a first side of the multilayer membrane and a fluid flow passageway on a second opposing side of the membrane, the flow control chamber being arranged to contain an actuator fluid and a gas creating a flow control chamber pressure, the multilayer membrane configured to affect flow through the fluid flow passageway from the entrance port to the exit port by deflecting in response to changes in the flow control chamber pressure, the multilayer membrane comprising;

a first base layer;

an adherent layer;

a regulating layer having a lower gas permeability and a lower flexibility than the first base layer, the regulating layer restricting diffusion of gas in the flow control chamber through the multilayer membrane; and

a second base layer;

wherein the adherent layer and the regulating layer are located between the first base layer and the second base layer, and the first base layer, the regulating layer, the adherent layer, and the second base layer form an integral membrane.

2. The IOP control device of claim 1, wherein the multilayer membrane is configured to reduce the gas permeability of the membrane to at least one type of gas.

3. The IOP control device of claim 2, wherein the regulating layer is shaped and configured to reduce the gas permeability of the membrane to hydrogen.

4. The IOP control device of claim 3, wherein the regulating layer includes gold.

5. The IOP control device of claim 2, wherein the regulating layer comprises a continuous layer in contact with the at least one of the first or second base layers.

6. The IOP control device of claim 2, wherein the at least one regulating layer comprises a non-continuous layer in contact with the first base layer.

7. The IOP control device of claim 1, wherein the adherent layer includes titanium.

8. The IOP control device of claim 1, wherein the multilayer membrane is shaped and configured as a flexible, corrugated membrane.

9. The IOP control device of claim 1, wherein the flow control chamber includes an actuator fluid and an electrolysis system configured to affect the flow control chamber pressure by generating bubbles by converting at least a portion of the actuator fluid to the gas.