Combinations of a pyrimidine containing NNRTI with RT inhibitors

  • US 8,841,310 B2
  • Filed: 10/07/2009
  • Issued: 09/23/2014
  • Est. Priority Date: 09/03/2003
  • Status: Active Grant
First Claim
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1. A combination comprising(i) 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]-amino]-2-pyrimidinyl]-amino]-benzonitrile, or a stereoisomeric form thereof;

  • or a pharmaceutically acceptable salt thereof, and(ii) tenofovir or its prodrug tenofovir disoproxil fumarate, and(iii) emtricitabine;

    wherein the 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]-amino]-2-pyrimidinyl]-amino]-benzonitrile, or a stereoisomeric form thereof;

    or a pharmaceutically acceptable salt thereof;

    the tenofovir or its prodrug tenofovir disoproxil fumarate; and

    the emtricitabine are therapeutically effective HIV inhibitors at a dose that can be administered once daily.

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