Combinations of a pyrimidine containing NNRTI with RT inhibitors
DCFirst Claim
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1. A combination comprising(i) 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]-amino]-2-pyrimidinyl]-amino]-benzonitrile, or a stereoisomeric form thereof;
- or a pharmaceutically acceptable salt thereof, and(ii) tenofovir or its prodrug tenofovir disoproxil fumarate, and(iii) emtricitabine;
wherein the 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]-amino]-2-pyrimidinyl]-amino]-benzonitrile, or a stereoisomeric form thereof;
or a pharmaceutically acceptable salt thereof;
the tenofovir or its prodrug tenofovir disoproxil fumarate; and
the emtricitabine are therapeutically effective HIV inhibitors at a dose that can be administered once daily.
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Abstract
The present invention concerns combinations of a pyrimidine containing NNRTI with nucleoside reverse transcriptase inhibitors and/or nucleotide reverse transcriptase inhibitors useful for the treatment of HIV infected patients or for the prevention of HIV transmission or infection.
20 Citations
33 Claims
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1. A combination comprising
(i) 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]-amino]-2-pyrimidinyl]-amino]-benzonitrile, or a stereoisomeric form thereof; - or a pharmaceutically acceptable salt thereof, and
(ii) tenofovir or its prodrug tenofovir disoproxil fumarate, and (iii) emtricitabine; wherein the 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]-amino]-2-pyrimidinyl]-amino]-benzonitrile, or a stereoisomeric form thereof;
or a pharmaceutically acceptable salt thereof;
the tenofovir or its prodrug tenofovir disoproxil fumarate; and
the emtricitabine are therapeutically effective HIV inhibitors at a dose that can be administered once daily. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33)
- or a pharmaceutically acceptable salt thereof, and
Specification