Microwave field stimulator

• US 8,849,412 B2
• Filed: 08/13/2012
• Issued: 09/30/2014
• Est. Priority Date: 01/28/2011
• Status: Active Grant

• Current Assignee: Curonix Company Limited
• Original Assignee: Micron Devices LLC
• Inventors: Perryman, Laura Tyler, Larson, Patrick, Andresen, Chad
• Primary Examiner(s): Kahelin, Michael
• Application Number:
  US13/584,618
• Publication Number:
  US 20130066400A1
• Time in Patent Office: 778 Days
• Field of Search: 607/59, 607/61
• US Class Current: 607/61
• CPC Class Codes: A61N 1/025 Digital circuitry features of electrotherapy devices, e.g. memory, clocks, processors
• CPC Class Codes: A61N 1/36125 Details of circuitry or electric components
• CPC Class Codes: A61N 1/36139 with automatic adjustment
• CPC Class Codes: A61N 1/36146 specified by the stimulation parameters
• CPC Class Codes: A61N 1/37223 Circuits for electromagnetic coupling
• CPC Class Codes: A61N 1/37229 Shape or location of the implanted or external antenna
• CPC Class Codes: A61N 1/37235 Aspects of the external programmer
• CPC Class Codes: A61N 1/37247 User interfaces, e.g. input or presentation means
• CPC Class Codes: A61N 1/37252 Details of algorithms or data aspects of communication system, e.g. handshaking, transmitting specific data or segmenting data
• CPC Class Codes: A61N 1/3727 characterised by the modulation technique

Abstract

A system includes a controller module, which includes a storage device, a controller, a modulator, and one or more antennas. The storage device is stored with parameters defining a stimulation waveform. The controller is configured to generate, based on the stored parameters, an output signal that includes the stimulation waveform, wherein the output signal additionally includes polarity assignments for electrodes in an implantable, passive stimulation device. The modulator modulates a stimulus carrier signal with the output signal to generate a transmission signal. The one or more antennas transmit the transmission signal to the implantable, passive stimulation device such that the implantable, passive stimulation device uses energy in the transmission signal for operation, sets the polarities for the electrodes in the implantable, passive stimulation device based on the encoded polarity assignments, generates electrical pulses using the stimulation waveform, and applies the electrical pulses to excitable tissue.

Claims

1. A system for modulating excitable tissue in a patient comprising:

an implantable passive neural stimulation device comprising one or more electrodes and an embedded dipole receiving antenna; and

a controller module comprising;

a storage device configured to store parameters defining a stimulation waveform and polarity assignments for the electrodes;

a controller configured to generate, based on the parameters, an output signal that includes the stimulation waveform and RF energy for operation of the implantable passive neural stimulation device, wherein the output signal additionally includes the polarity assignments for the electrodes in the implantable passive neural stimulation device;

a modulator configured to modulate a carrier signal with the output signal to generate a transmission signal, wherein the carrier signal has a frequency between about 800 MHz to 6 GHz; and

one or more antennas configured to transmit the transmission signal to the implantable passive neural stimulation device such that the implantable passive neural stimulation device uses energy solely from the transmission signal for operation without the need for long term energy storage in the implantable passive neural stimulation device, sets the polarities for the electrodes in the implantable passive neural stimulation device based on the polarity assignments, generates electrical pulses using the RF energy from the transmission signal, and applies the electrical pulses to the excitable tissue, when the implantable passive neural stimulation device is placed at a target site 1 cm to 6 cm below an outer skin surface of the patient and when the controller module is placed at a location exterior to the patient and spaced away from the outer skin of the patient.

2. The system of claim 1 wherein:

the stimulation waveform includes a sequence of pulses and the parameters include at least one of;

a pulse duration, pulse amplitude, and a pulse repetition rate; and

the output signal generated by the controller includes a configuration portion that encodes the polarity assignments and a stimulation portion that includes the stimulation waveform.

3. The system of claim 2, wherein the controller module is configured to:

generate the transmission signal such that the transmission signal has an initial power-on portion that precedes the configuration portion and the stimulation portion, the initial power-on portion being sent to the implantable passive neural stimulation device as part of the transmission signal such that the implantable passive neural stimulation device stores energy from the initial power-on portion and sends a power-on event signal when the energy reaches a threshold amount.

4. The system of claim 3, wherein the controller module is further configured to:

receive the power-on event signal from the implantable passive neural stimulation device;

in response to receiving the power-on event signal, generate the configuration portion that is sent to the implantable passive neural stimulation device; and

after generating the configuration portion, generate the stimulation portion.

5. The system of claim 2, wherein the configuration portion includes multiple waveforms that encode the polarity assignments.

6. The controller module of claim 1 further comprising a rechargeable power source configured to be managed by a power management protocol.

7. The system of claim 6, wherein the rechargeable power source includes one of:

a lithium-ion battery, a lithium polymer battery.

8. The system of claim 1, further comprising a programmer module having a visual programming interface to enable a user to program the controller module.

9. The system of claim 8, wherein the visual programming module is configured to authenticate the user and thereafter provide access control to the user.

10. The system of claim 1, wherein:

the one or more antennas are further configured to receive telemetry feedback signals from the implantable passive stimulation device in response to the transmission signal, and

the controller is further configured to modify the output signal by using a closed-loop feedback control based on the received telemetry feedback signal.

11. The system of claim 10, wherein the controller is further programmed to apply the closed-loop feedback control by:

ascertaining a distortion to the electrical pulses as applied by the electrodes of the implantable, passive neural stimulation device, the distortion caused by at least one of a transmission characteristic of the antenna, a characteristic of the implantable passive neural stimulator, or an impedance characteristic of the tissue; and

adjusting the stimulation waveform embedded in the transmission signal to compensate for the distortion such that the electrical pulses as applied are substantially undistorted despite the transmission characteristic of the antenna, the characteristic of the implantable passive neural stimulator, or the impedance characteristic of the tissue.

12. The system of claim 11, wherein the distortion is characterized as a frequency response corresponding to at least one of the transmission characteristic of the antenna, the characteristic of the implantable passive neural stimulator, and the impedance characteristic of the tissue.

13. The system of claim 12, wherein the controller is configured to adjust the stimulation waveform by filtering the transmission signal according to an inverse of the frequency response, performing linear pre-equalization for the transmit signal.

14. The system of claim 10, wherein the controller is further programmed to apply the closed-loop feedback control by:

monitoring a stimulus amplitude being directed to the excitable tissue through the electrodes based on information contained in the telemetry feedback signal; and

adjusting a parameter associated with the stimulation waveform embedded in the transmission signal such that the stimulus amplitude remains substantially constant.

15. The system of claim 14, wherein the controller is further configured to change the stimulus amplitude based on patient body movement.

16. The system of claim 14, wherein the parameter is an amplitude level associated with the stimulation waveform embedded in the transmission signal, and the amplitude level is adjusted based on known relationship between the amplitude level and a corresponding stimulus amplitude applied to the tissue through the electrodes.

17. The system of claim 14 wherein the controller is further configured to adjust the parameter by modifying the carrier frequency within a range of up to 10megahertz.

18. The system of claim 1, wherein the storage device comprises non-volatile memory including at least one of:

an EEPROM, a flash memory.

19. The system of claim 1, wherein the controller module is configured for placement exterior to the patient within a 3-feet radius of the implantable passive neural stimulation device.

20. The system of claim 1, wherein the controller module is configured for a sub-cutaneous implantation in a patient.