Pharmaceutical compositions for the coordinated delivery of NSAIDS

  • US 8,858,996 B2
  • Filed: 04/03/2014
  • Issued: 10/14/2014
  • Est. Priority Date: 06/01/2001
  • Status: Active Grant
First Claim
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1. A pharmaceutical composition in unit dosage form in the form of a tablet, said composition comprising:

  • naproxen in an amount of 200-600 mg per unit dosage form; and

    esomeprazole in an amount of from 5 to 100 mg per unit dosage form,wherein upon introduction of said unit dosage form into a medium, at least a portion of said esomeprazole is released regardless of the pH of the medium, and release of at least a portion of said naproxen is inhibited unless the pH of said medium is 3.5 or higher.

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