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Techniques to improve polyurethane membranes for implantable glucose sensors

  • US 8,865,249 B2
  • Filed: 09/28/2012
  • Issued: 10/21/2014
  • Est. Priority Date: 05/22/2002
  • Status: Expired due to Term
First Claim
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1. A method for preparing an implantable membrane for an implantable glucose sensor, the method comprising:

  • forming a composition including a dispersion of a first polymer within a matrix of a second polymer;

    maintaining the composition at a temperature sufficient to maintain solubility;

    applying the composition at the temperature to at least one of a substrate or a layer on the substrate to form a film thereon, wherein the step of maintaining the composition precedes the step of applying the composition; and

    drying the film to form a membrane configured to cover at least a portion of an electrode of the implantable glucose sensor, wherein the membrane is configured to allow passage of glucose therethrough;

    whereby after a sample of the membrane is hydrated for two hours the sample membrane exhibits no observable hydrated domains under photomicroscopy at 400×

    magnification.

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