Circulatory monitoring systems and methods

• US 8,870,813 B2
• Filed: 05/22/2008
• Issued: 10/28/2014
• Est. Priority Date: 12/18/2007
• Status: Expired due to Fees

• Current Assignee: Gearbox LLC (Intellectual Ventures LLC)
• Original Assignee: The Invention Science Fund I, L.L.C. (Intellectual Ventures LLC)
• Inventors: Ferren, Bran, Hagen, Jeffrey John, Hyde, Roderick A., Ishikawa, Muriel Y., Leuthardt, Eric C., Rivet, Dennis J., Wood, Lowell L. Jr., Wood, Victoria Y. H.
• Primary Examiner(s): Lucchesi, Nicholas
• Assistant Examiner(s): LANDRY II, GERALD ERNEST
• Application Number:
  US12/154,654
• Publication Number:
  US 20090156988A1
• Time in Patent Office: 2,350 Days
• Field of Search: 604/27, 604/30, 604/31, 604/43, 604/65, 604/66, 604/266
• US Class Current: 604/66
• CPC Class Codes: A61B 2562/02 Details of sensors specially adapted for in-vivo measurements
• CPC Class Codes: A61B 2562/0233 Special features of optical sensors or probes classified in A61B5/00
• CPC Class Codes: A61B 2562/0247 Pressure sensors
• CPC Class Codes: A61B 2562/046 in a matrix array
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/015 By temperature mapping of body part
• CPC Class Codes: A61B 5/0205 Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• CPC Class Codes: A61B 5/02055 Simultaneously evaluating both cardiovascular condition and temperature
• CPC Class Codes: A61B 5/026 Measuring blood flow A61B3/1233, A61B3/1241 take precedence
• CPC Class Codes: A61B 5/412 Detecting or monitoring sepsis
• CPC Class Codes: A61B 5/415 the glands, e.g. tonsils, adenoids or thymus
• CPC Class Codes: A61B 5/418 lymph vessels, ducts or nodes
• CPC Class Codes: A61B 5/6804 Garments; Clothes
• CPC Class Codes: A61B 5/6807 Footwear
• CPC Class Codes: A61B 5/6833 Adhesive patches
• CPC Class Codes: A61B 5/6843 Monitoring or controlling sensor contact pressure
• CPC Class Codes: A61B 5/6848 Needles
• CPC Class Codes: A61B 5/6862 Stents
• CPC Class Codes: A61B 5/6876 Blood vessel
• CPC Class Codes: A61B 5/6887 mounted on external non-worn devices, e.g. non-medical devices
• CPC Class Codes: A61B 8/06 : Measuring blood flow measuring volume flow in general G01F, e.g. G01F1/66, G01F1/72; measuring speed of fluids in general G01P5/00
• CPC Class Codes: A61B 8/4472 : Wireless probes
• CPC Class Codes: A61B 8/4483 : characterised by features of the ultrasound transducer
• CPC Class Codes: A61F 2250/0002 : for data transfer
• CPC Class Codes: A61M 2005/1726 : the body parameters being measured at, or proximate to, the infusion site
• CPC Class Codes: A61M 2025/1052 : for temporarily occluding a vessel for isolating a sector
• CPC Class Codes: A61M 2039/2413 : designed to reduce and or shut-off the flow when a certain maximum flow limit is exceeded
• CPC Class Codes: A61M 2039/242 : designed to open when a predetermined pressure or flow rate has been reached, e.g. check valve actuated by fluid
• CPC Class Codes: A61M 2039/248 : Ball-valve
• CPC Class Codes: A61M 2205/04 : implanted
• CPC Class Codes: A61M 2205/3507 : with implanted devices, e.g. external control
• CPC Class Codes: A61M 2205/3561 : local, e.g. within room or hospital
• CPC Class Codes: A61M 2205/3592 : using telemetric means, e.g. radio or optical transmission
• CPC Class Codes: A61M 31/00 : Devices for introducing or retaining media, e.g. remedies, in cavities of the body A61M25/00 takes precedence ; introducing or retaining ophthalmic products into the ocular cavities A61F9/0008
• CPC Class Codes: A61M 39/24 : Check- or non-return valves
• CPC Class Codes: A61M 5/14276 : specially adapted for implantation
• CPC Class Codes: A61M 5/16831 : Monitoring, detecting, signalling or eliminating infusion flow anomalies low-level float-valves causing cut-off A61M5/40; indicating or recording presence, absence or direction of flow in general G01P13/0066
• CPC Class Codes: A61M 5/1723 : using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: G16H 40/63 : for local operation
• CPC Class Codes: G16Z 99/00 : Subject matter not provided for in other main groups of this subclass

Abstract

Systems and methods are described for obtaining and acting upon information indicative of circulatory health and related phenomena in human beings or other subjects. Some involve implementing or deploying therapeutic administration systems, for example, for obtaining a priori implant information and signaling a decision whether to initiate implant-site-targeting treatment; or obtaining a flow-change-indicative measurement and signaling a decision whether to administer a clot-reducing agent; or obtaining an indication of a lytic material in a vicinity of a body lumen and accelerating a decrease in a local concentration of the lytic material to extract at least a portion of the lytic material in response to the indication; or a capture component configured to accelerate a decrease in a local concentration of a therapeutic structure along a downstream portion of a vasculature and a dispensation component configured to release the therapeutic structure into an upstream portion of the vasculature.

Claims

1. A medical or veterinary system comprising:

circuitry for signaling a decision to initiate a site-targeting treatment;

a first artificial structure configured to administer a therapeutic material containing at least an artificial component via one or more capillaries of a vasculature locally responsive to the decision; and

a second artificial structure configured to extract a portion of the therapeutic material out of the vasculature.

2. The medical or veterinary system of claim 1, further comprising:

a third artificial structure, configured to support the first artificial structure and the second artificial structure.

3. The medical or veterinary system of claim 1, further comprising:

a third artificial structure, configured to facilitate positioning at least a distal portion of the first artificial structure in the vasculature.

4. The medical or veterinary system of claim 1, further comprising:

another artificial structure, configured to implement one or more balloons to occlude a portion of the vasculature.

5. The medical or veterinary system of claim 1, further comprising:

circuitry for detecting a presence of the therapeutic material.

6. The medical or veterinary system of claim 1, further comprising:

circuitry for indicating a release of the therapeutic material.

7. The medical or veterinary system of claim 1, further comprising:

circuitry for triggering the second artificial structure responsive to one or more physical phenomena.

8. The medical or veterinary system of claim 1 in which the first artificial structure comprises:

the first artificial structure, configured to administer the therapeutic material to a vital organ via the one or more capillaries.

9. The medical or veterinary system of claim 3 in which the first artificial structure comprises:

a reservoir configured to contain the artificial component, including one or more of an antiaggregant or a lethal amount of another drug; and

a transvascular dispensation conduit configured to administer the therapeutic material via one or more venules of the vasculature locally to the one or more capillaries of the vasculature.

10. The medical or veterinary system of claim 9 in which the second artificial structure comprises:

an absorbent element operable to absorb the portion of the therapeutic material.

11. The medical or veterinary system of claim 9 in which the second artificial structure comprises:

a transvascular disposal conduit.

12. The medical or veterinary system of claim 3 in which the second artificial structure comprises:

a pump to convey the portion of the therapeutic material out of the vasculature.

13. The medical or veterinary system of claim 3 in which the second artificial structure comprises:

circuitry for applying one or more thresholds.

16. The medical or veterinary system of claim 9 in which the second artificial structure comprises:

a filtration device permeable to the portion of the therapeutic material.

17. The medical or veterinary system of claim 3 in which the first artificial structure comprises:

a reservoir configured to contain the artificial component, including one or more of an antiaggregant or a lethal amount of another drug; and

the therapeutic material, including at least blood and the artificial component.

18. The medical or veterinary system of claim 17, further comprising:

circuitry for indicating a release of the therapeutic material; and

circuitry for triggering the second artificial structure responsive to one or more physical phenomena.

19. The medical or veterinary system of claim 17, further comprising:

circuitry for triggering the second artificial structure responsive to one or more physical phenomena.

20. The medical or veterinary system of claim 3, further comprising:

another artificial structure, configured to implement a controlled occlusion of a portion of the vasculature;

circuitry for detecting a presence of the therapeutic material; and

circuitry for triggering the second artificial structure responsive to one or more physical phenomena.

21. The medical or veterinary system of claim 3, further comprising:

another artificial structure, configured to implement a controlled occlusion of a portion of the vasculature; and

circuitry for triggering the second artificial structure responsive to one or more physical phenomena.

22. The medical or veterinary system of claim 3, further comprising:

another artificial structure, configured to implement a controlled occlusion of a portion of the vasculature;

circuitry for detecting a presence of the therapeutic material; and

circuitry for indicating a release of the therapeutic material.

14. A medical or veterinary system comprising:

a first artificial structure configured to administer a therapeutic material containing at least an artificial component via one or more capillaries of a vasculature locally;

a second artificial structure configured to extract a portion of the therapeutic material out of the vasculature;

a third artificial structure, configured to facilitate positioning at least a distal portion of the first artificial structure in the vasculature;

another artificial structure, configured to implement one or more balloons to occlude a portion of the vasculature;

circuitry for detecting a presence of the therapeutic material;

circuitry for indicating a release of the therapeutic material; and

circuitry for triggering the second artificial structure responsive to one or more physical phenomena.

15. The medical or veterinary system of claim 14 in which the first artificial structure comprises:

a reservoir configured to contain the artificial component, including one or more of an antiaggregant or a lethal amount of another drug;

the therapeutic material, including at least blood and the artificial component; and

a transvascular dispensation conduit configured to administer the therapeutic material via one or more venules of the vasculature locally to the one or more capillaries of the vasculature.