Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9)

  • US 8,871,914 B2
  • Filed: 04/24/2014
  • Issued: 10/28/2014
  • Est. Priority Date: 08/23/2007
  • Status: Active Grant
First Claim
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1. An isolated human monoclonal antibody that binds to an epitope on PSCK9, wherein the epitope comprises at least one of amino acid residues S123, E129, A311, D313, or D337 of SEQ ID NO:

  • 1, and wherein the monoclonal antibody blocks binding of PCSK9 to LDLR.

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