Immunogenic composition

  • US 8,883,163 B2
  • Filed: 02/27/2013
  • Issued: 11/11/2014
  • Est. Priority Date: 06/27/2005
  • Status: Active Grant
First Claim
Patent Images

1. A method of immunising a human host against disease caused by Haemophilus influenza (Hib) comprising administering to the human host an immunoprotective dose of an immunogenic composition, wherein the immunogenic composition comprises:

  • a Hib saccharide conjugate;

    a Neisseria meningitidis (N. meningitidis) capsular saccharide conjugate derived from a strain selected from the group consisting of serogroup A, serogroup B, serogroup C, serogroup W135 and serogroup Y; and

    an antigen selected from the group consisting of whole cell pertussis and hepatitis B surface antigen, wherein the saccharide dose of the Hib saccharide conjugate is less than 5 μ

    g and the saccharide dose of the N. meningitidis capsular saccharide conjugate is less than 8 μ

    g, and wherein the Geometric Mean Concentration (GMC) for the antigen achieved with said immunogenic composition is higher than the GMC achieved after immunisation with said immunogenic composition containing a 5 μ

    g saccharide dose of Hib saccharide conjugate and an 8 μ

    g dose of N. meningitidis capsular saccharide conjugate.

View all claims
    ×
    ×

    Thank you for your feedback

    ×
    ×