Systems and methods of fluidic sample processing
First Claim
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1. A method of detecting an analyte in a bodily fluid from a subject, comprising:
- a) providing a fluidic device comprising a sample collection unit, an assay assembly, and a calibration unit, wherein,i) said sample collection unit is configured to collect a sample of the bodily fluid from said subject, comprises an anticoagulant, and is removable from the fluidic device;
ii) said assay assembly comprises at least one reaction site containing a reactant configured to react with said analyte to yield a detectable signal indicative of the presence of said analyte; and
iii) said calibration unit is configured to provide a measurement of said sample used for calibrating said detectable signal;
b) allowing a portion of said sample to react with assay reagents contained within said assay assembly to yield a signal indicative of the presence of said analyte in said sample; and
c) detecting said signal generated from said analyte in said sample of bodily fluid.
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Abstract
The present invention provides fluidic devices and systems that allow detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications.
239 Citations
11 Claims
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1. A method of detecting an analyte in a bodily fluid from a subject, comprising:
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a) providing a fluidic device comprising a sample collection unit, an assay assembly, and a calibration unit, wherein, i) said sample collection unit is configured to collect a sample of the bodily fluid from said subject, comprises an anticoagulant, and is removable from the fluidic device; ii) said assay assembly comprises at least one reaction site containing a reactant configured to react with said analyte to yield a detectable signal indicative of the presence of said analyte; and iii) said calibration unit is configured to provide a measurement of said sample used for calibrating said detectable signal; b) allowing a portion of said sample to react with assay reagents contained within said assay assembly to yield a signal indicative of the presence of said analyte in said sample; and c) detecting said signal generated from said analyte in said sample of bodily fluid. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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Specification