Fusion protein of Exendin-4 and its analog, preparation method and use thereof

  • US 8,889,619 B2
  • Filed: 06/10/2011
  • Issued: 11/18/2014
  • Est. Priority Date: 06/11/2010
  • Status: Active Grant
First Claim
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1. A fusion protein obtained by fusing a peptide hormone to a transport protein via a linker, wherein the peptide hormone is capable of lowering the blood glucose, the transport protein is the Fc fragment of the immunoglobulin IgG2, and the fusion protein is capable of lowering the blood glucose;

  • the peptide hormone is exendin-4, which has the amino acid sequence set forth in SEQ ID NO;

    1, and the linker is a peptide consisting of the sequence of (Gly)m-Xaa-(Gly)n, in which m is an integer between 3 and 8, n is an integer between 3 and 8, and Xaa is any one selected from the group consisting of Gly, Ser, Ala and Thr.

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