Tamper resistant dosage forms

  • US 8,894,988 B2
  • Filed: 05/23/2013
  • Issued: 11/25/2014
  • Est. Priority Date: 08/25/2006
  • Status: Active Grant
First Claim
Patent Images

1. A cured shaped tablet comprising an extended release matrix comprising a composition, wherein said tablet comprises:

  • (1) at least one polyethylene oxide having, based on rheological measurements, an approximate molecular weight of 4,000,000, and(2) oxycodone or a pharmaceutically acceptable salt, andwherein said tablet is prepared by a process comprising the steps of;

    (a) combining at least (1) and (2) to form a blend;

    (b) shaping said blend to form a shaped tablet; and

    (c) curing said shaped tablet by subjecting the shaped tablet to a temperature from about 60 to about 90°

    C. for a time of from about 15 minutes to about 10 hours, wherein said cured shaped tablet comprises;

    (i) 5, 7.5, 10, 15, 20, or 30 mg of said oxycodone or pharmaceutically acceptable salt and at least 79% by weight, based upon the total weight of said composition, of said at least one polyethylene oxide having, based on rheological measurements, an approximate molecular weight of 4,000,000;

    (ii) 40 mg of said oxycodone or pharmaceutically acceptable salt and at least 72% by weight, based upon the total weight of said composition, of said at least one polyethylene oxide having, based on rheological measurements, an approximate molecular weight of 4,000,000;

    (iii) 60 mg of said oxycodone or pharmaceutically acceptable salt and at least 57% by weight, based upon the total weight of said composition, of said at least one polyethylene oxide having, based on rheological measurements, an approximate molecular weight of 4,000,000;

    or(iv) 80 mg of said oxycodone or pharmaceutically acceptable salt and at least 54% by weight, based upon the total weight of said composition, of said at least one polyethylene oxide having, based on rheological measurements, an approximate molecular weight of 4,000,000.

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