Composition and method for treating neurological disease

  • US 8,895,616 B1
  • Filed: 08/04/2014
  • Issued: 11/25/2014
  • Est. Priority Date: 11/24/2004
  • Status: Active Grant
First Claim
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1. A method comprising:

  • orally administering to a human subject with Parkinson'"'"'s disease a once-daily dose consisting of (i) 200 mg to 500 mg of a drug selected from the group consisting of amantadine and pharmaceutically acceptable salts thereof, and (ii) at least one excipient, wherein at least 50% of the drug in the dose is in an extended release form, and wherein the dose provides a mean change in amantadine plasma concentration as a function of time (dC/dT) as measured in a single dose human pharmacokinetic study over the time period between 2 hours and 4 hours after administration that is less than 30% of the dC/dT provided by the same quantity of the drug in an immediate release form as measured in a single dose human pharmacokinetic study over the time period between 0 and 2 hours after administration.

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