Two piece cancellous construct for cartilage repair

• US 8,906,110 B2
• Filed: 09/14/2010
• Issued: 12/09/2014
• Est. Priority Date: 01/24/2007
• Status: Active Grant

• Current Assignee: Musculoskeletal Transplant Foundation
• Original Assignee: Musculoskeletal Transplant Foundation
• Inventors: Semler, Eric J., Truncale, Katherine G., Callahan, Alex B., Yannariello-Brown, Judith I.
• Primary Examiner(s): Sweet, Thomas J
• Assistant Examiner(s): HOBAN, MELISSA A
• Application Number:
  US12/881,988
• Publication Number:
  US 20110224797A1
• Time in Patent Office: 1,547 Days
• Field of Search: 623/23.63
• US Class Current: 623/23.51
• CPC Class Codes: A61B 17/00491 Surgical glue applicators surgical adhesives A61L24/00; two-component delivery syringes A61M5/19
• CPC Class Codes: A61F 2/28 Bones joints A61F2/30
• CPC Class Codes: A61F 2/30756 Cartilage endoprostheses A61F2/3603 takes precedence
• CPC Class Codes: A61F 2/3859 Femoral components
• CPC Class Codes: A61F 2002/2817 Bone stimulation by chemical reactions or by osteogenic or biological products for enhancing ossification, e.g. by bone morphogenetic or morphogenic proteins [BMP] or by transforming growth factors [TGF]
• CPC Class Codes: A61F 2002/2835 Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
• CPC Class Codes: A61F 2002/2839 Bone plugs or bone graft dowels
• CPC Class Codes: A61F 2002/30057 made from both cortical and cancellous adjacent parts
• CPC Class Codes: A61F 2002/30059 differing in bone mineralization, e.g. made from both mineralized and demineralized adjacent parts
• CPC Class Codes: A61F 2002/30225 Flat cylinders, i.e. discs
• CPC Class Codes: A61F 2002/30227 arched, domed or vaulted
• CPC Class Codes: A61F 2002/30233 Stepped cylinders, i.e. having discrete diameter changes
• CPC Class Codes: A61F 2002/30235 tubular, e.g. sleeves
• CPC Class Codes: A61F 2002/30327 differing in diameter
• CPC Class Codes: A61F 2002/30354 Cylindrically-shaped protrusion and recess, e.g. cylinder of circular basis
• CPC Class Codes: A61F 2002/30448 using adhesives
• CPC Class Codes: A61F 2002/30459 stapled
• CPC Class Codes: A61F 2002/30461 sutured, ligatured or stitched
• CPC Class Codes: A61F 2002/30492 using a locking pin
• CPC Class Codes: A61F 2002/30604 modular
• CPC Class Codes: A61F 2002/30759 : Mosaicplasty, i.e. using a plurality of individual cartilage plugs for filling a substantial cartilage defect
• CPC Class Codes: A61F 2002/30762 : Means for culturing cartilage
• CPC Class Codes: A61F 2002/30764 : Cartilage harvest sites
• CPC Class Codes: A61F 2002/30772 : Apertures or holes, e.g. of circular cross section
• CPC Class Codes: A61F 2002/30785 : parallel
• CPC Class Codes: A61F 2002/30789 : perpendicular with respect to each other
• CPC Class Codes: A61F 2002/30795 : Blind bores, e.g. of circular cross-section
• CPC Class Codes: A61F 2002/30932 : for retarding or preventing ingrowth of bone tissue
• CPC Class Codes: A61F 2002/4635 : using minimally invasive surgery
• CPC Class Codes: A61F 2002/4646 : Devices for cleaning bone graft
• CPC Class Codes: A61F 2002/4649 : Bone graft or bone dowel harvest sites
• CPC Class Codes: A61F 2220/0025 : Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
• CPC Class Codes: A61F 2220/0033 : made by longitudinally pushing a protrusion into a complementary-shaped recess, e.g. held by friction fit
• CPC Class Codes: A61F 2220/005 : using adhesives
• CPC Class Codes: A61F 2220/0066 : stapled
• CPC Class Codes: A61F 2220/0075 : sutured, ligatured or stitched, retained or tied with a rope, string, thread, wire or cable
• CPC Class Codes: A61F 2230/0069 : cylindrical
• CPC Class Codes: A61F 2250/0039 : differing in diameter
• CPC Class Codes: A61F 2310/00365 : Proteins; Polypeptides; Degradation products thereof
• CPC Class Codes: A61L 2300/414 : Growth factors
• CPC Class Codes: A61L 2300/64 : Animal cells
• CPC Class Codes: A61L 2430/06 : for cartilage reconstruction, e.g. meniscus
• CPC Class Codes: A61L 27/3608 : Bone, e.g. demineralised bone matrix [DBM], bone powder
• CPC Class Codes: A61L 27/3654 : Cartilage, e.g. meniscus
• CPC Class Codes: A61L 27/38 : containing added animal cells organs or tissue containing native cells A61L27/36
• CPC Class Codes: A61L 27/54 : Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence

Abstract

The invention is directed toward a cartilage repair assembly comprising a shaped allograft two piece construct with a demineralized cancellous cap and a mineralized cylindrical base member defining a blind bore with a through-going transverse bore intersecting the blind bore. The demineralized cancellous cap has a cylindrical top portion and a smaller diameter cylindrical stem extending away from the top portion which fits into the blind bore of the mineralized base member. The cap stem defines a transverse through-going bore which is aligned with the through-going bore of the base member to receive a cylindrical cortical pin holding the cap within the base member. The shaped structure is dimensioned to fit in a drilled bore in a cartilage defect area so that the assembly engages the side wall of the drilled bore in an interference fit.

Claims

1. In a multi-component construct for cartilage and bone repair, said construct having an outer periphery whose size and shape are selected such that said construct is positionable in a defect site to be repaired, said construct including a cap member shaped to form a stem having a longitudinal axis, which defines an axial direction, and a top section attached to one end of said stem and extending radially outward therefrom, said top section having first and second opposed surfaces, said first surface being sized and shaped so as to be adjacent an original cartilage layer at the defect site when said construct is positioned therein, and a base member sized and shaped so as to be adjacent a subchondral bone layer at the defect site when said construct is positioned therein, said base member including a proximal end proximate said second surface of said top section when said multi-component construct is assembled, a distal end remote from said cap member when said multi-component construct is assembled, and a blind bore extending in said axial direction from said proximal end toward said distal end, said blind bore being sized and shaped so as to receive said stem of said cap member, the improvement wherein:

said cap member is formed from a first piece of cancellous bone which is demineralized to thereby provide said top section and said stem of said cap member with an elastic quality, said top section including a first sidewall having a first diameter;

said base member is formed from a second, separate piece of cancellous bone that is mineralized, whereby said base member does not have an elastic quality, said base member including a second sidewall having a second diameter which is substantially equal to, but not greater than, said first diameter, whereby said proximal end of said base member is substantially coextensive with said top section of said cap member and wherein said first and second diameters are selected such that said outer periphery of said construct is delimited by said first sidewall of said top section of said cap member, and by said second sidewall of said base member; and

said second surface of said top section of said cap member is in direct contact with said proximal end of said base member upon assembly of said multi-component construct, whereby said base member supports said top section such that said first surface of said top section is substantially flush with an outer surface of the original cartilage layer at the defect site.

2. The construct of claim 1, wherein said blind bore of said base member includes a bottom surface intermediate said proximal end of said base member and said distal end of said base member.

3. The construct of claim 2, wherein an opposite end of said stem, remote from said top section of said cap member, is in direct contact with said bottom surface of said blind bore of said base member upon assembly of said multi-component construct.

4. The construct of claim 1, wherein said first surface of said top section is a planar top surface.

5. The construct of claim 1, wherein said first piece of cancellous bone has a calcium content of less than 0.2%.

6. The construct of claim 1, wherein said cap member is treated to be non-osteoinductive.