Flux limiting membrane for intravenous amperometric biosensor
First Claim
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1. A flux limiting membrane for an intravenous amperometric biosensor, comprising:
- an ethylene vinylacetate (EVA) polymer at least partially coating a glucose oxidase reagent, wherein the glucose oxidase reagent is disposed on an electrode of the biosensor wherein the ethylene vinylacetate polymer comprising hydrophilic segments selectively limiting diffusion of glucose from circulating intravenous blood to the glucose oxidase reagent,wherein the EVA composition has a vinyl acetate content between about 9 wt % and about 50 wt %.
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Abstract
A flux limiting layer for an intravenous amperometric biosensor is formed on a substrate to limit a diffusion rate of an analyte from blood to an enzyme electrode. The layer may be formed from ethylene vinylacetate (EVA) dissolved in a solvent such as paraxylene, spray-coated to cover a portion of the electrode, and cured to seal the electrode to the substrate. In a glucose sensor having glucose oxidase disposed on the electrode, thickness and concentration of the EVA layer are optimized to promote a linear output of electrode current as a function of blood glucose concentration.
35 Citations
20 Claims
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1. A flux limiting membrane for an intravenous amperometric biosensor, comprising:
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an ethylene vinylacetate (EVA) polymer at least partially coating a glucose oxidase reagent, wherein the glucose oxidase reagent is disposed on an electrode of the biosensor wherein the ethylene vinylacetate polymer comprising hydrophilic segments selectively limiting diffusion of glucose from circulating intravenous blood to the glucose oxidase reagent, wherein the EVA composition has a vinyl acetate content between about 9 wt % and about 50 wt %. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. An intravenous amperometric biosensor, comprising:
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a flexible dielectric substrate; a reference electrode, a counter electrode, and working electrode bonded to the substrate; a glucose oxidase reagent layer disposed on the working electrode; and an ethylene vinylacetate (EVA) flux limiting membrane at least partially coating the glucose oxidase reagent layer and working electrode, wherein the EVA flux limiting membrane comprises hydrophilic segments selectively limiting diffusion of glucose from circulating intravenous blood to the glucose oxidase reagent, wherein the EVA composition has a vinyl acetate content between about 9 wt. % and about 40 wt %. - View Dependent Claims (10, 11, 12, 13, 14, 15)
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16. A flux limiting membrane comprising:
an ethylene vinylacetate (EVA) polymer bound to an enzyme electrode configured for intravenous positioning, the ethylene vinylacetate (EVA) polymer having a generally hydrophobic property to diffuse oxygen and sufficient hydrophilic segments to selectively limit glucose transport from circulating venous blood to an intravenously positioned enzyme electrode, the ethylene vinylacetate (EVA) polymer membrane comprising a vinyl acetate content between about 9 wt. % and about 40 wt. %. - View Dependent Claims (17, 18)
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19. A biosensor comprising:
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an intravenous amperometric enzyme electrode bonded to a substrate; and an ethylene vinylacetate (EVA) polymer membrane at least partially coating the enzyme electrode and the substrate, the ethylene vinylacetate (EVA) comprising a vinyl acetate content between about 9 wt % and about 40 wt %; wherein the ethylene vinylacetate (EVA) polymer membrane comprises a generally hydrophobic property to diffuse oxygen and sufficient hydrophilic segments to selectively limit glucose transport from circulating venous blood to the intravenously positioned enzyme electrode. - View Dependent Claims (20)
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Specification