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Generation and maintenance of stem cells

  • US 8,906,677 B2
  • Filed: 12/16/2009
  • Issued: 12/09/2014
  • Est. Priority Date: 12/17/2008
  • Status: Active Grant
First Claim
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1. A method of culturing pluripotent cells through at least one cell division, the method comprising, culturing pluripotent animal cells in the presence of a sufficient amount of:

  • a) an ALK5 inhibitor;

    b) a second compound selected from one or more of a MEK inhibitor, an Erk inhibitor, a p38 inhibitor, and an FGF receptor inhibitor;

    c) a GSK3β

    inhibitor; and

    d) nutrients;

    to allow for at least one cell division while maintaining cell pluripotency.

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