Integration of very short electric pulses for minimally to noninvasive electroporation
First Claim
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1. A method of treating a subject suffering from an aberrant cell growth, said method comprising:
- implanting an electrode into or adjacent the aberrant growth region within the body of a subject, andcausing a train of electrical pulses to be emitted from the electrode into the aberrant growth region, wherein each individual pulse in the pulse train is incapable of IRE alone but together as the pulse train capable of causing predominately non-thermal killing of aberrantly growing cells by IRE.
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Abstract
The present invention provides methods, devices, and systems for in vivo treatment of cell proliferative disorders. The invention can be used to treat solid tumors, such as brain tumors. The methods rely on non-thermal irreversible electroporation (IRE) or supra-poration to cause cell death in treated tumors. In embodiments, the methods comprise the integration of ultra-short electric pulses, both temporally and spatially, to achieve the desired modality of cell death.
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27 Claims
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1. A method of treating a subject suffering from an aberrant cell growth, said method comprising:
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implanting an electrode into or adjacent the aberrant growth region within the body of a subject, and causing a train of electrical pulses to be emitted from the electrode into the aberrant growth region, wherein each individual pulse in the pulse train is incapable of IRE alone but together as the pulse train capable of causing predominately non-thermal killing of aberrantly growing cells by IRE. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A method of treating a subject suffering from an aberrant cell growth, said method comprising:
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contacting the subject with a first electrode, placing at least two additional electrodes outside the subject'"'"'s body at positions that permit electrical charges to be delivered to the aberrant cell growth, and causing a train of electrical pulses to be emitted from one or more of the electrodes into the aberrant growth region in, wherein each pulse is incapable of IRE alone but together as the pulse train capable of causing predominately non-thermal killing of aberrantly growing cells by IRE. - View Dependent Claims (22, 23, 24, 25, 26)
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27. A method of treating a subject suffering from an aberrant growth, said method comprising:
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implanting an electrode into or adjacent the aberrant growth, and causing a train of electrical pulses to be emitted from the electrode into the aberrant growth in, wherein each pulse is incapable of reversible electroporation alone, wherein the pulse train is capable of causing reversible electroporation of cells of the aberrant growth and/or cells adjacent the aberrant growth, which results in uptake of bioactive substances into the treated cells.
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Specification