Bio-film resistant surfaces

• US 8,932,624 B2
• Filed: 06/06/2008
• Issued: 01/13/2015
• Est. Priority Date: 06/20/2007
• Status: Active Grant

• Current Assignee: Trustees Of Columbia University In The City Of New York (Columbia University)
• Original Assignee: Trustees Of Columbia University In The City Of New York (Columbia University)
• Inventors: Modak, Shanta M., Caraos, Lauserpina A., Citron, Ronald, Geraldo, Ingrid
• Primary Examiner(s): PACKARD, BENJAMIN J
• Application Number:
  US12/134,911
• Publication Number:
  US 20090029961A1
• Time in Patent Office: 2,412 Days
• Field of Search: 424/447
• US Class Current: 424/447
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 25/34 Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
• CPC Class Codes: A01N 37/36 containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
• CPC Class Codes: A01N 47/44 Guanidine; Derivatives thereof
• CPC Class Codes: A01N 59/16 Heavy metals; Compounds thereof
• CPC Class Codes: A61L 15/46 Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
• CPC Class Codes: A61L 2300/104 Silver, e.g. silver sulfadiazine
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: A61P 31/02 Local antiseptics

Abstract

The present invention relates to methods and compositions for rendering a surface resistant to bio-film formation by a combination of an alkanediol and an antimicrobial agent (and, optionally, an organic hydroxy acid). The invention provides for compositions which may be used to render surfaces bio-film resistant, articles having bio-film resistant surfaces, and methods for their preparation. The present invention may be advantageously applied to medical articles as well as articles used in non-medical contexts, such as child care or food preparation.

Claims

1. A composition for preparing a bio-film resistant surface comprising

(i) an antimicrobial composition consisting of a biguanide present at between about 0.1 and 5 percent (weight/volume), an alkanediol present at between about 0.5 and 5 percent (volume/volume), and one or more hydroxy acid present at between about 0.5 and 3 percent (volume/volume), wherein the alkanediol and hydroxy acid are present in amounts that increase the antimicrobial effect of the biguanide and

(ii) a solvent selected from the group consisting of an alcohol, tetrahydrofuran, and mixtures thereof.

2. The composition of claim 1, wherein the biguanide is selected from the group consisting of chlorhexidine free base, chlorhexidine diacetate, chlorhexidine gluconate, polyhexamethylene biguanide, and a mixture thereof.

3. The composition of claim 1, wherein the alkanediol is selected from the group consisting of octanediol, 1,2-decanediol, 1,2-dodecanediol, 1,12-dodecanediol and 1,2 tetradecanediol.

4. The composition of claim 1, further comprising an additional antimicrobial agent in an amount between about 0.05 and 3 percent (weight/volume).

5. The composition of claim 4, wherein the additional antimicrobial agent is a silver compound.

6. The composition of claim 5, wherein the silver compound is silver sulfadiazine.

7. The composition of claim 1, wherein the hydroxy acid is selected from the group consisting of lactic acid, citric acid, and salicylic acid.

8. The composition of claim 1, comprised in a wipe.

9. The composition of claim 2, comprised in a wipe.

10. The composition of claim 3, comprised in a wipe.

11. The composition of claim 4, comprised in a wipe.

12. The composition of claim 5, comprised in a wipe.

13. The composition of claim 6, comprised in a wipe.

14. The composition of claim 7, comprised in a wipe.

15. The composition of claim 1, comprised in a wound dressing.

16. The composition of claim 2, comprised in a wound dressing.

17. The composition of claim 3, comprised in a wound dressing.

18. The composition of claim 4, comprised in a wound dressing.

19. The composition of claim 5, comprised in a wound dressing.

20. The composition of claim 6, comprised in a wound dressing.

21. The composition of claim 7, comprised in a wound dressing.

22. The composition of claim 1, further comprising a polymer.

23. The composition of claim 22, comprised in a wipe.

24. The composition of claim 22, comprised in a wound dressing.

25. The composition of claim 4, wherein the additional antimicrobial agent is a chlorinated phenol.

26. The composition of claim 4, wherein the additional antimicrobial agent is triclosan.