Interfering RNA molecules

  • US 8,933,215 B2
  • Filed: 12/03/2012
  • Issued: 01/13/2015
  • Est. Priority Date: 08/05/2002
  • Status: Active Grant
First Claim
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1. A nucleic acid molecule comprising a first strand and a second strand,wherein said first strand comprises a first stretch that is complementary to a target nucleic acid,wherein said second strand comprises a second stretch that is complementary to said first stretch,wherein said first strand and said second strand form a double-stranded structure comprising said first stretch and said second stretch,wherein said nucleic acid molecule is blunt ended on at least one end, andwherein each stretch consists of at least 15 and fewer than 30 ribonucleotides and wherein said first stretch and said second stretch each comprises contiguous alternating modified ribonucleotides, said alternating modified ribonucleotides alternating with unmodified or differently modified ribonucleotides.

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