Interfering RNA molecules
DCFirst Claim
1. A nucleic acid molecule comprising a first strand and a second strand,wherein said first strand comprises a first stretch that is complementary to a target nucleic acid,wherein said second strand comprises a second stretch that is complementary to said first stretch,wherein said first strand and said second strand form a double-stranded structure comprising said first stretch and said second stretch,wherein said nucleic acid molecule is blunt ended on at least one end, andwherein each stretch consists of at least 15 and fewer than 30 ribonucleotides and wherein said first stretch and said second stretch each comprises contiguous alternating modified ribonucleotides, said alternating modified ribonucleotides alternating with unmodified or differently modified ribonucleotides.
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Abstract
The present invention is related to a ribonucleic acid comprising a double stranded structure whereby the double-stranded structure comprises a first strand and a second strand, whereby the first strand comprises a first stretch of contiguous nucleotides and whereby said first stretch is at least partially complementary to a target nucleic acid, and the second strand comprises a second stretch of contiguous nucleotides whereby said second stretch is at least partially identical to a target nucleic acid, and whereby the double stranded structure is blunt ended.
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19 Claims
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1. A nucleic acid molecule comprising a first strand and a second strand,
wherein said first strand comprises a first stretch that is complementary to a target nucleic acid, wherein said second strand comprises a second stretch that is complementary to said first stretch, wherein said first strand and said second strand form a double-stranded structure comprising said first stretch and said second stretch, wherein said nucleic acid molecule is blunt ended on at least one end, and wherein each stretch consists of at least 15 and fewer than 30 ribonucleotides and wherein said first stretch and said second stretch each comprises contiguous alternating modified ribonucleotides, said alternating modified ribonucleotides alternating with unmodified or differently modified ribonucleotides.
Specification