Computer-implemented electrocardiograhic data processor with time stamp correlation

• US 8,938,287 B2
• Filed: 01/07/2014
• Issued: 01/20/2015
• Est. Priority Date: 10/08/2010
• Status: Active Grant

• Current Assignee: Zoll Medical Corporation (Asahi Kasei Corporation)
• Original Assignee: Cardiac Science Operating Company (Cardica Incorporated)
• Inventors: Felix, Jason, Bardy, Gust H.
• Primary Examiner(s): Lavert, Nicole F
• Application Number:
  US14/149,463
• Publication Number:
  US 20140200472A1
• Time in Patent Office: 378 Days
• Field of Search: 607/31, 607/59, 600/5, 600/513
• US Class Current: 600/513
• CPC Class Codes: A61B 5/30 Input circuits therefor
• CPC Class Codes: A61B 5/316 Modalities, i.e. specific diagnostic methods
• CPC Class Codes: A61B 5/332 Portable devices specially adapted therefor
• CPC Class Codes: A61B 5/333 Recording apparatus specially adapted therefor
• CPC Class Codes: A61B 5/339 Displays specially adapted therefor
• CPC Class Codes: A61B 5/7203 for noise prevention, reduction or removal
• CPC Class Codes: A61B 5/7232 involving compression of the physiological signal, e.g. to extend the signal recording period

Abstract

A computer-implemented electrocardiographic data processor with time stamp correlation is provided. A monitoring circuit includes a persistent memory and power supply that powers an encoder that determines a differential voltage between a current discrete digital voltage value and a prior voltage value. The differential voltage is stored into the persistent memory in a digitized data stream representative of analog cardiac action potential signals. Digitally-encoded voltage values and time stamps are retrieved from the persistent memory. A post-processing application executes. A set of output voltages and voltage differences that each correspond to lower and upper bounds of voltage is stored. Each retrieved voltage value is compared to the voltage bounds and the voltage differences within which each retrieved voltage value falls is identified. The output voltages corresponding to the voltage differences is selected. A display depicts the output voltages as reproduced analog cardiac action potential signals and correlates the time stamps.

Claims

1. A computer-implemented electrocardiographic data processor with feedback cancellation, comprising:

a download station, comprising;

a data interface configured to physically interface to an electrocardiographic monitoring circuit, the monitoring circuit comprises a persistent memory and an onboard power supply that powers an encoder configured to determine a differential voltage between a current discrete digital voltage value and a prior discrete digital voltage value, the differential voltage is stored into the persistent memory in a digitized data stream representative of analog cardiac action potential signals; and

a data retrieval module configured to retrieve digitally-encoded voltage values and feedback markers recorded by the monitoring circuit from the persistent memory of the monitoring circuit via the data interface; and

a post-processing application configured to execute on a computer that is interfaced with the download station, comprising;

an onboard digital data store comprising a set of enumerated output voltages and enumerated ranges of voltage differences that each correspond to lower and upper bounds of voltage;

a bias settings module configured to determine, based on the retrieved feedback markers, bias control settings used during recording of the analog cardiac action potential signals;

a comparator configured to compare each normalized voltage value to the lower and upper bounds of voltage and to identify the enumerated range within which each normalized voltage value falls;

a decoder configured to select the output voltages corresponding to the identified enumerated ranges as a reproduction of the analog cardiac action potential signals; and

a feedback cancellation module configured to determine a contribution from feedback introduced by application of the bias control settings and to subtract the feedback contribution from the reproduced analog cardiac action potential signals.

2. A data processor according to claim 1, further comprising:

a resolution extension module further configured to extend resolution of each retrieved voltage value as a function of the subtraction of the feedback contribution before analog cardiac action potential signals reproduction.

3. A data processor according to claim 2, wherein the data resolution of each retrieved voltage value is expressed by a number of bits n in accordance with an equation:

4. A data processor according to claim 1, wherein the feedback energy contribution E_RLD is determined by solving an equation:

5. A data processor according to claim 4, wherein a voltage of the feedback energy contribution E.sub.RLD is determined by solving an equation:

6. A data processor according to claim 1, further comprising:

the set of enumerated output voltages further comprising mirrored pairs of positive and negative output voltages that exponentially increase with a number of bits used to encode each discrete digital voltage value.

7. A data processor according to claim 1, further comprising:

a signal modeler configured to interpret a discrete variable slope encoding implicit in the digitally-encoded voltage values as recorded in the persistent memory of the monitoring circuit into the reproduced analog cardiac action potential signals based on the output voltages.

8. A computer-implemented electrocardiographic data processor with voltage depletion compensation, comprising:

a download station, comprising;

a data interface configured to physically interface to an electrocardiographic monitoring circuit, the monitoring circuit comprises a persistent memory and an onboard power supply that powers an encoder configured to determine a differential voltage between a current discrete digital voltage value and a prior discrete digital voltage value, the differential voltage is stored into the persistent memory in a digitized data stream representative of analog cardiac action potential signals; and

a data retrieval module configured to retrieve digitally-encoded voltage values recorded by the monitoring circuit over a fixed monitoring period from the persistent memory of the monitoring circuit via the data interface; and

a post-processing application configured to execute on a computer that is interfaced with the download station, comprising;

an onboard digital data store comprising a set of enumerated output voltages and enumerated ranges of voltage differences that each correspond to lower and upper bounds of voltage;

a reference voltage module configured to determine an adjusted voltage of the power supply for each retrieved voltage value as a function of the number of voltage values recorded prior to the retrieved voltage value;

a voltage normalizer configured to normalize each retrieved voltage value against the power supply'"'"'s adjusted voltage;

a comparator configured to compare each normalized voltage value to the lower and upper bounds of voltage and to identify the enumerated range within which each normalized voltage value falls; and

a decoder configured to select the output voltages corresponding to the identified enumerated ranges as a reproduction of the analog cardiac action potential signals.

9. A data processor according to claim 8, further comprising:

a voltage scaler configured to scale the power supply'"'"'s adjusted voltage based on a number of write operations of voltage values into the persistent memory up to that point in the monitoring period; and

a voltage adjuster configured to determine each normalized voltage value based on placement of that voltage value within an ordering of all of the voltage values in the persistent memory.

10. A data processor according to claim 8, wherein a normalized voltage V for each retrieved voltage value is determined based on the equation:

11. A data processor according to claim 8, further comprising:

the set of enumerated output voltages further comprising mirrored pairs of positive and negative output voltages that exponentially increase with a number of bits used to encode each discrete digital voltage value.

12. A data processor according to claim 8, further comprising:

a signal modeler configured to interpret a discrete variable slope encoding implicit in the digitally-encoded voltage values as recorded in the persistent memory of the monitoring circuit into the reproduced analog cardiac action potential signals based on the output voltages.

13. A microcontrolled electrocardiographic monitoring system, comprising:

microcontrolled electrocardiographic monitoring circuit, comprising;

a microcontroller circuit comprising an input codec, comprising;

an analog-to-digital converter connected to a filtered amplified analog input signal path and configured to convert the input signal into a data stream of discrete digital values;

an encoder configured to determine a differential voltage between a current digital value and a prior digital value in the data stream;

a feedback generator configured to identify a pairing of drive resistor settings matched to each digital value in the data stream and to output the drive resistor settings as a digital feedback signal; and

a drive resistor adjuster configured to adjust each drive resistor in an output signal path according to the digital feedback signal; and

persistent memory connected to the microcontroller circuit configured to store the differential voltages for each of the digital values;

a download station, comprising;

a data interface configured to physically interface to the monitoring circuit; and

a data retrieval module configured to retrieve digitally-encoded data values representative of analog cardiac action potential signals from the persistent memory of the monitoring circuit via the data interface; and

a post-processing application configured to execute on a computer that is interfaced with the download station, comprising;

 

an onboard digital data store comprising a set of enumerated output voltages and enumerated ranges of voltage differences that each correspond to lower and upper bounds of voltage;

 

a comparator configured to compare each retrieved data value to the lower and upper bounds of voltage and to identify the enumerated range within which each retrieved data value falls; and

 

a decoder configured to select the output voltages corresponding to the identified enumerated ranges as a reproduction of the input signal.

14. A system according to claim 13, further comprising:

the filtered amplified analog input signal path comprising an electrode, a low pass filter, and an amplifier, each connected in-line, the electrode configured to sense an input signal via a conductive surface and the amplifier configured to output the filtered amplified analog input signal.

15. A system according to claim 13, further comprising:

the output signal path comprising an electrode and a buffer, each connected in-line, with the pair of drive resistors connected in parallel to an input terminal of the buffer and to the output terminals of the feedback generator, the electrode configured to provide an output signal via a conductive surface.

16. A system according to claim 13, further comprising:

the persistent memory further configured to store a copy of the set of enumerated ranges of voltage differences; and

the microcontroller circuit further comprising a selector configured to assign an encoded value to each of the enumerated ranges, to identify the enumerated range within which the differential voltage falls and to select the encoded value corresponding to the identified enumerated range.

17. A system according to claim 13, further comprising:

the set of enumerated output voltages further comprising mirrored pairs of positive and negative output voltages that exponentially increase with a number of bits used to encode each discrete digital voltage value.

18. A system according to claim 13, further comprising:

a signal modeler configured to interpret a discrete variable slope encoding implicit in the digitally-encoded voltage values as recorded in the persistent memory of the monitoring circuit into the reproduced analog cardiac action potential signals based on the output voltages.