Abuse-resistant pharmaceutical composition for the treatment of opioid dependence

  • US 8,940,330 B2
  • Filed: 09/18/2012
  • Issued: 01/27/2015
  • Est. Priority Date: 09/19/2011
  • Status: Active Grant
First Claim
Patent Images

1. A tablet composition suitable for sublingual administration comprising:

  • microparticles of a pharmacologically-effective amount of buprenorphine, or a pharmaceutically-acceptable salt thereof, presented upon the surface of carrier particles, wherein microparticles of buprenorphine or a pharmaceutically acceptable salt thereof are in contact with particles comprising citric acid, wherein the buprenorphine or pharmaceutically acceptable salt thereof and the citric acid are not in the same particle;

    a pharmacologically-effective amount of naloxone, or a pharmaceutically-acceptable salt thereof; and

    a disintegrant selected from the group consisting of croscarmellose sodium, sodium starch glycolate, crosslinked polyvinylpyrrolidone and mixtures thereof.

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