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Detecting, assessing and managing epilepsy using a multi-variate, metric-based classification analysis

  • US 8,945,006 B2
  • Filed: 02/24/2014
  • Issued: 02/03/2015
  • Est. Priority Date: 10/01/2010
  • Status: Active Grant
First Claim
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1. A method comprising:

  • detecting a plurality of seizure events based upon body data of the patient;

    determining, for each seizure event, at least one seizure metric value characterizing the seizure event, wherein each of said at least one seizure metric values comprises one of an autonomic index, a neurologic index, a metabolic index, an endocrine index, a tissue index, or a tissue stress index;

    performing a first classification analysis of a first portion of the plurality of seizure events, the first classification analysis comprising assigning each seizure event in the first portion to at least one seizure class based upon the proximity of the seizure metric values to each other;

    performing a second classification analysis of a second portion of the plurality of seizure events, the second classification analysis comprising assigning each seizure event in the second portion to at least one seizure class based upon the proximity of the seizure metric values, wherein said second portion comprises at least one seizure event not present in the first portion;

    comparing the results of the first classification analysis and the second classification analysis;

    andperforming a further action selected from;

    a. reporting a change from the first classification to the second classification;

    b. reporting the absence of a change from the first classification to the second classification;

    c. displaying a result of at least one of the first classification analysis, the second classification analysis, and the comparing;

    d. identifying the emergence of a new class based on the comparing;

    e. identifying the disappearance of a prior class based on the comparing;

    f. identifying one or more outlier seizure events not part of any class;

    g. identifying an effect of a therapy;

    h. providing a therapy to the patient in response to the comparing;

    i. identifying a proposed change in therapy;

    j. identifying a proposed additional therapy;

    k. identifying an extreme seizure event.l. identifying a worsening trend in the patient'"'"'s seizures;

    m. identifying an improvement trend in the patient'"'"'s seizures;

    n. downgrading the patient'"'"'s condition in response to a worsening in the patient'"'"'s seizures; and

    o. upgrading the patient'"'"'s condition in response to an improvement in the patient'"'"'s seizures.

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