Method and device for the treatment of glaucoma

• US 8,951,221 B2
• Filed: 08/20/2009
• Issued: 02/10/2015
• Est. Priority Date: 08/20/2009
• Status: Active Grant

• Current Assignee: Grieshaber Ophthalmic Research Foundation
• Original Assignee: Grieshaber Ophthalmic Research Foundation
• Inventors: Stegmann, Robert Christopher, Grieshaber, Matthias Christian, Grieshaber, Hans Rudolf
• Primary Examiner(s): Zalukaeva, Tatyana
• Assistant Examiner(s): TREYGER, ILYA Y
• Application Number:
  US12/544,637
• Publication Number:
  US 20110046536A1
• Time in Patent Office: 2,000 Days
• Field of Search: 604/5.04, 604 8- 10
• US Class Current: 604/8
• CPC Class Codes: A61B 2090/3937 Visible markers
• CPC Class Codes: A61B 2090/3941 Photoluminescent markers
• CPC Class Codes: A61F 9/0017 implantable in, or in contact with, the eye, e.g. ocular inserts
• CPC Class Codes: A61F 9/00781 Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment drainage implants in general A61M27/002

Abstract

The invention relates to a method and device for the treatment of glaucoma, though insertion of an implant into the lumen of the Schlemm'"'"'s canal to realize proper drainage of the aqueous humor, which implant is brought into its position in the Schlemm'"'"'s canal by means of a catheter having a distal and a proximate portion and provided with a number of pores through which a gaseous or fluid medium which comes from a pressure source can emerge during insertion of the catheter carrying the implant into the Schlemm'"'"'s canal, and while the catheter is being inserted into the Schlemm'"'"'s canal the gaseous or fluid medium is released under pressure thereby expanding the Schlemm'"'"'s canal and the implant and upon releasing the implant at its determined location, the catheter can be withdrawn from the Schlemm'"'"'s canal.

Claims

1. A device for treatment of glaucoma, comprising:

a catheter having proximal and distal portions;

a flexible tubular implant configured with at least one connecting part extending along an axial extension of the implant for bearing at an inner wall at the Schlemm'"'"'s canal, and radial ring members arranged in axial direction and connected to the connecting part and spaced-apart from each other by gaps, said implant placed entirely over the distal portion of the catheter for insertion into the Schlemm'"'"'s canal in a direction of a target site,

wherein the distal portion has spaced-apart bores in communication with an interior space of both, the catheter and the implant for injecting a medium under pressure at the target site to expand the implant and release the implant from the catheter at the target site to thereby allow withdrawal of the catheter, wherein the proximate portion is connected to a pressure source.

2. The device of claim 1, wherein the distal portion and the implant each have a length dimension corresponding to a circumferential length of the Schlemm'"'"'s canal from a point of insertion of the distal portion into the exposed Schlemm'"'"'s canal to a point where the exposed Schlemm'"'"'s canal ended.

3. The device of claim 1, wherein the distal portion is removably connected to the proximate portion by means of a coupling, the coupling has a diameter corresponding to the outer diameter of the implant and includes a circular bearing surface at a side facing the implant.

4. The device of claim 1, wherein the distal portion includes a head piece configured as a cap of semi-circular shape with at least one bore in communication with the interior of the catheter.

5. The device of claim 4, wherein the head piece, beginning from the outer diameter of the distal portion is tapered into a tip having a bore in communication with the interior of the catheter.

6. The device of claim 4, wherein the head piece is made of a light-reflecting and biocompatible material.

7. The device of claim 4, wherein the head piece is coated with a light reflecting and biocompatible foil.

8. The device of claim 1, wherein the bores are distributed circumferentially and along an entire axial length of the distal portion.

9. The device of claim 8, wherein the bores are configured as pores which act as nozzles having a diameter from 10 μ

m to 25 μ

m.

10. The device of claim 9, wherein the bores are laser cut into the distal portion by an Excimer laser.

11. The device of claim 1, wherein the ring parts are divided into two ring members by an axially oriented gap, wherein the two ring members are movable relative to each other such that the gap can be increased for removal of the catheter.

12. The device of claim 11, wherein the gap is at a location on the ring part approximately opposite the connecting part.

13. The device of claim 12, wherein the two ring members are movable relative to each other upon an increase or decrease of pressure from the pressure medium.

14. The device of claim 13, wherein the gap between the ring member is approximately U-shaped or approximately Z-shaped with the ring members shaped in correspondence to the shape of the gap.

15. The device of claim 1, wherein the recesses between the ring parts have an opening angle (W) from 90°

to 105°

.

16. The device of claim 1, wherein the recesses between the ring parts have an opening angle (W) from 280°

to 290°

.

17. The device of claim 1, wherein the implant having a generally circular cross section includes two axially extending connecting parts disposed opposite from each other in circumferential direction and ring members arranged at the connection parts spaced-apart from each other by gaps, wherein one of the connecting parts is provided with a slot-shaped gap extending in axial direction and another one of the connecting parts has a surface of a shape for supporting an inner wall of the Schlemm'"'"'s canal.

18. The device of claim 17, wherein the shape of the other one of the connecting parts has a circular arced surface.

19. The device of claim 17, wherein the gaps between the ring members have an opening angle from 90°

to 105°

.

20. The device of claim 1, wherein the implant is made of a material selected from the group consisting of biocompatible material, plastic, stainless steel, special steel, silver, gold, platinum and nitinol.

21. The device of claim 20, wherein the implant is made from polymeric material having thermal or mechanical shape memory.

22. The device of claim 20, wherein the implant is provided with a biocompatible coating.

23. The device of claim 22, wherein the coating is heparin.

24. A device for treatment of glaucoma, comprising:

a catheter having proximal and distal portions;

a tubular-shaped unitary implant configured with at least one connecting part extending along an axial extension of the implant for bearing at an inner wall at the Schlemm'"'"'s canal, and radial ring members arranged in axial direction and connected to the connecting part and spaced-apart from each other by gaps, said implant having a plurality of openings placed in full length over the distal portion of the catheter for combined insertion into the Schlemm'"'"'s canal in a direction of a target site,

wherein the distal portion has spaced-apart bores in communication with an interior space of both, the catheter and the implant such that for injecting a medium injected under pressure at the target site for expanding can expand the implant so that the implant is released from the catheter at the target site when the catheter is withdrawn.