Device for detecting an analyte

• US 8,956,519 B2
• Filed: 03/25/2010
• Issued: 02/17/2015
• Est. Priority Date: 03/25/2009
• Status: Active Grant

• Current Assignee: Parker Intangibles LLC (Parker-Hannifin Corporation)
• Original Assignee: Senova Systems, Inc.
• Inventors: Leonard, Lee, Duimstra, Joseph A., Lee, Eric, Micklatcher, Mark, Simonyi, Victor, Wildgoose, Gregory G., Keto, Joseph I., Seidl, Anton
• Primary Examiner(s): DIETERLE, JENNIFER M
• Application Number:
  US13/258,647
• Publication Number:
  US 20120090995A1
• Time in Patent Office: 1,790 Days
• Field of Search: 204/406, 204/416, 422/82.03, 73/10.5, 73/530.1
• US Class Current: 204/416
• CPC Class Codes: G01N 27/302 pH sensitive, e.g. quinhydron, antimony or hydrogen electrodes ion selective electrodes G01N27/333, glass electrodes G01N27/36
• CPC Class Codes: G01N 27/4166 measuring a particular property of an electrolyte
• CPC Class Codes: G01N 27/4167 pH electrodes therefor G01N27/302, G01N27/36

Abstract

Devices for detecting an analyte comprising a redox active analyte sensitive material on a working electrode and computer assisted signal acquisition and processing.

Claims

1. A pH meter device, comprising:

a probe assembly having a first end, a second end and a central axis;

a reference electrode having a frit disposed at the first end of the probe assembly;

a working electrode comprising an analyte sensitive material coupled to a substrate, the analyte sensitive material and the substrate being disposed at the first end of the probe assembly;

a counter electrode disposed at the first end of the probe assembly;

an enclosure disposed at the second end of the probe assembly;

a pre-amplification circuit disposed within the enclosure and electrically coupled to the reference electrode, the working electrode and the counter electrode; and

a processor electrically coupled to the pre-amplification circuit for detecting an analyte by voltammetry, wherein the reference electrode, the working electrode and the counter electrode are coaxially positioned relative to the central axis, and wherein the pre-amplification circuit scales a signal received from the working electrode,

wherein the reference electrode is a cartridge assembly coaxially disposed within the counter electrode, the reference electrode comprising (a) a first electrolyte solution contained by said cartridge assembly that can be placed in electrical contact with an analyte solution via a frit at one end of said cartridge assembly; and

(b) a mini reference assembly disposed within the cartridge assembly, the mini reference assembly comprising;

a casing having a first end and a second end, the first end of the casing having an opening for receiving a frit member and the second end of the casing having an opening for receiving an electrode wire having a first end and a second end, the first end being electrically coupled to the pre-amplification circuit, and the second end being exposed to a second electrolyte solution contained by the casing, wherein said second electrolyte solution is in electrical contact with said first electrolyte solution via said frit member, and at least a portion of the electrode wire is positioned proximate to the working electrode, such that the temperature of the electrode wire is substantially similar to the temperature of the working electrode.

2. The pH meter device of claim 1, wherein the analyte sensitive material is selected from the group consisting of anthraquinone described by the following Formula I:

3. The pH meter device of claim 1, wherein the analyte sensitive material is covalently attached to the substrate via a chemical linker.

4. The pH meter device of claim 1, wherein the analyte sensitive material is physisorbed within the substrate.

5. The pH meter device of claim 1, wherein the substrate is selected from the group consisting of a noble metal material, a semiconductive material, a conductive metal alloy material, a conductive polymeric compound, and a carbon-based material.

6. The pH meter device of claim 5, wherein the carbon-based material is selected from the group consisting of a carbon allotrope material, a pyrolytic graphite material, graphite, amorphous carbon, carbon black, single-walled carbon nanotubes, multi-walled carbon nanotubes, glassy carbon, boron-doped diamonds, and pyrolyzed photoresist films.

7. The pH meter device of claim 1 further comprising, a clip device for securing the probe assembly to a vessel, the clip device comprising:

an aperture for receiving a portion of the probe assembly; and

a body coupled to the aperture, the body having a first arm for receiving a rim surface of the vessel such that the aperture is located proximate to an interior of the vessel and the first arm is located proximate to an exterior of the vessel.

8. The pH meter device of claim 1 further comprising, a storage device comprising an enclosure having a base portion selectively coupled to a cover portion, the base portion having a well for receiving a wetting solution, the cover portion having an aperture for supporting a shaft portion of the probe assembly, the aperture being in approximate alignment with the well such that upon insertion of the probe assembly into the aperture, a tip portion of the probe assembly is submerged in the wetting solution.