Chemical reaction cartridge, method of producing chemical reaction cartridge, and mechanism for driving chemical reaction cartridge

• US 8,961,900 B2
• Filed: 04/20/2005
• Issued: 02/24/2015
• Est. Priority Date: 04/28/2004
• Status: Active Grant

• Current Assignee: Yokogawa Electric Corporation
• Original Assignee: Yokogawa Electric Corporation
• Inventors: Tanaami, Takeo, Katakura, Hisao, Mitsumori, Yuji, Hiramatsu, Hitoshi
• Primary Examiner(s): LEVKOVICH, NATALIA A
• Application Number:
  US11/111,216
• Publication Number:
  US 20050244308A1
• Time in Patent Office: 3,597 Days
• Field of Search: 422/102, 422/103, 422/104
• US Class Current: 422/503
• CPC Class Codes: B01F 33/30 Micromixers
• CPC Class Codes: B01F 35/712 for feeding fluids
• CPC Class Codes: B01F 35/714 for feeding predetermined amounts B01F35/88 takes precedence
• CPC Class Codes: B01F 35/7177 using rollers
• CPC Class Codes: B01J 19/0093 Microreactors, e.g. miniaturised or microfabricated reactors laboratory containers with capillary fluid transport in microfabricated channels or chambers B01L3/5027
• CPC Class Codes: B01J 2219/00783 Laminate assemblies, i.e. the reactor comprising a stack of plates
• CPC Class Codes: B01J 2219/00804 Plurality of plates
• CPC Class Codes: B01J 2219/00833 Plastic
• CPC Class Codes: B01L 2200/0621 Control of the sequence of chambers filled or emptied
• CPC Class Codes: B01L 2200/0684 Venting, avoiding backpressure, avoid gas bubbles
• CPC Class Codes: B01L 2200/10 Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
• CPC Class Codes: B01L 2300/0681 Filter
• CPC Class Codes: B01L 2300/0816 Cards, e.g. flat sample carriers usually with flow in two horizontal directions
• CPC Class Codes: B01L 2300/0861 Configuration of multiple channels and/or chambers in a single devices
• CPC Class Codes: B01L 2300/0864 comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
• CPC Class Codes: B01L 2300/0867 Multiple inlets and one sample wells, e.g. mixing, dilution
• CPC Class Codes: B01L 2300/087 Multiple sequential chambers
• CPC Class Codes: B01L 2400/0481 squeezing of channels or chambers
• CPC Class Codes: B01L 2400/0655 pinch valves
• CPC Class Codes: B01L 3/502707 characterised by the manufacture of the container or its components by shaping or joining plastic parts B29C59/00, B29C65/00; by laminating B32B37/00; manufacture of microstructural devices in general B81C
• CPC Class Codes: B01L 3/502723 : characterised by venting arrangements
• CPC Class Codes: B01L 3/50273 : characterised by the means or forces applied to move the fluids micropumps F04B19/006, of the membrane type F04B43/043

Abstract

A chemical reaction cartridge includes a vessel having at least one part made of an elastic body, in which a plurality of chambers formed in the vessel so as to be connected or arranged connectably through a flow path, and an external force is applied to the elastic body from an outside of the vessel to move a fluid substance in the flow path or the chambers or in both the flow path and the chambers so as to perform a chemical reaction. At least a chamber into which the fluid substance is flowed has an air-release path which releases air from the chamber.

Claims

1. A chemical reaction cartridge comprising:

a substrate; and

an elastic body comprising a plurality of chambers formed therein and a plurality of flow paths connecting the plurality of chambers, the elastic body being configured to facilitate movement of a fluid substance through the flow paths and the chambers in response to an external force applied to the elastic body, to thereby perform a chemical reaction,

wherein the substrate and the elastic body are adhesively bonded to each other in first regions, which are regions other than the flow paths and the chambers, and the substrate and the elastic body are not adhesively bonded but are only brought into contact with each other by an elastic force of the elastic body in second regions, which are regions comprising the flow paths and the chambers, the elastic body being adhesively bonded at the first regions and elastically stretched out across the second regions such that the flow paths and the chambers are configured to;

take a first position in which a surface of the substrate and a surface of the elastic body directly contact each other at the second regions such that the flow paths and the chambers have zero volume before the fluid substance is moved by action of the external force, and

take a second position in which the flow paths and the chambers have a volume corresponding to the fluid substance moved into the flow paths and the chambers by the action of the external force.

2. The chemical reaction cartridge according to claim 1,

wherein the plurality of chambers are arranged at regular intervals of a pitch,

at least one of the chambers is a common chamber having a plurality of inlet flow paths into which different fluid substances are input, and at least one outlet flow path, and

at least one of the chambers is a dummy chamber for adjusting a timing of transporting a predetermined fluid substance into the common chamber.

3. The chemical reaction cartridge according to claim 1, further comprising:

an entrance for storing a predetermined amount of the fluid substance; and

a sucking portion which sucks the predetermined amount of the fluid substance stored in the entrance, into an inside part of one of the chambers.

4. The chemical reaction cartridge according to claim 1,

wherein at least one of the chambers is a common chamber having a plurality of the flow paths functioning as inlet flow paths into which two or more kinds of different fluid substances flow respectively, and at least two of the flow paths functioning as outlet flow paths, and

when one of the fluid substances flows into or from the common chamber, an inlet flow path for another fluid substance and the outlet flow paths are blocked by the external force.

5. The chemical reaction cartridge according to claim 4,

wherein the flow paths into and from which the another fluid substance flows are formed in positions to be blocked by an external force used for transporting the one fluid substance.

6. The chemical reaction cartridge according to claim 4,

wherein the plurality of chambers have convex portions which are pressed down when the external force is applied, and

a flow path for transporting the one fluid substance is formed in concave portions between the convex portions.

7. The chemical reaction cartridge according to claim 1,

wherein at least one of the chambers is a common chamber having a plurality of inlet flow paths into which two or more kinds of different fluid substances flow respectively, and at least two outlet flow paths, and

a plurality of flow paths passing through the common chamber are arranged in each of rear and front surfaces of the chemical reaction cartridge.

8. The chemical reaction cartridge according to claim 1,

wherein at least one of the chambers is a common chamber having a plurality of the flow paths through which two or more kinds of different fluid substances flow into and from the common chamber, and

the flow paths of the common chamber are arranged adjacently and linearly with the common chamber as its center, and

when one fluid substance flows into and from the common chamber, a flow path into which another fluid substance flows to flow into the common chamber is blocked by the external force.

9. The chemical reaction cartridge according to claim 1,

wherein the plurality of chambers are arranged at regular intervals of a pitch,

at least one of the chambers is a common chamber having a plurality of the flow paths functioning as inlet flow paths into which two or more kinds of different fluid substances flow respectively, and at least two of the flow paths functioning as outlet flow paths, and

when one fluid substance flows into and from the common chamber, an inlet flow path into which another fluid substance flows is blocked by the external force.

10. The chemical reaction cartridge according to claim 9, further comprising a pressurizing portion,

wherein a direction of movement of the pressurizing portion through which the external force is applied and a direction of one of the flow paths are different from each other.

11. The chemical reaction cartridge according to claim 10,

wherein the direction of the flow path is at an angle of 90 degrees or lower with respect to the direction of the movement of the pressurizing portion.

12. The chemical reaction cartridge according to claim 9,

further comprising a solid body formed on a side of the flow path,

wherein an external force is applied on a part of the flow path so that a solid body forming portion blocks the flow path entirely.

13. The chemical reaction cartridge according to claim 10,

further comprising a solid body formed on a side of the flow path,

wherein an external force is applied on part of the flow path so that a solid body forming portion blocks the flow path entirely.

14. The chemical reaction cartridge according to claim 1, further comprising an implantable material that is provided in the second regions comprising the flow paths and the chambers between the substrate and the elastic body, wherein the substrate and the elastic body are brought into contact with the implantable material.

15. The chemical reaction cartridge according to claim 1, wherein, in the second regions, the flow paths and the chambers have a substantially complete absence of air therein such that an amount of air in the second regions is collectively less than a preset amount.