Analyte sensor

• US 8,968,198 B2
• Filed: 01/30/2012
• Issued: 03/03/2015
• Est. Priority Date: 02/22/2006
• Status: Active Grant

• Current Assignee: DexCom Incorporated
• Original Assignee: DexCom Incorporated
• Inventors: Brauker, James H., Kamath, Apurv Ullas
• Primary Examiner(s): D'ANGELO, MICHAEL J
• Application Number:
  US13/361,820
• Publication Number:
  US 20120130214A1
• Time in Patent Office: 1,128 Days
• Field of Search: 600/309, 600345-347, 600/365
• US Class Current: 600/365
• CPC Class Codes: A61B 5/0004 characterised by the type of physiological signal transmitted
• CPC Class Codes: A61B 5/002 Monitoring the patient using a local or closed circuit, e.g. in a room or building A61B5/0017 takes precedence
• CPC Class Codes: A61B 5/1411 by percutaneous method, e.g. by lancet
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1473 invasive, e.g. introduced into the body by a catheter A61B5/1482 takes precedence
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes
• CPC Class Codes: A61B 5/15142 Devices intended for single use, i.e. disposable
• CPC Class Codes: A61B 5/72 Signal processing specially adapted for physiological signals or for diagnostic purposes character recognition, recognising digital ink, document-oriented image-based pattern recognition G06V30/00; recognition or understanding of postal images G06V30/424
• CPC Class Codes: A61B 5/742 using visual displays A61B5/339 takes precedence
• CPC Class Codes: A61B 5/746 Alarms related to a physiological condition, e.g. details of setting alarm thresholds or avoiding false alarms alarms per se G08B

Abstract

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

Claims

1. A glucose sensor system for monitoring glucose concentration in a biological sample of a host, the system comprising:

a continuous glucose sensor configured to produce a data stream indicative of a host'"'"'s glucose concentration;

a first device coupled to the continuous glucose sensor, the first device comprising sensor electronics housed within the first device, the sensor electronics comprising a transceiver configured to wirelessly transmit and receive data and a first processor configured to prospectively convert uncalibrated sensor data associated with the data stream using a prospectively-generated conversion function to generate real-time calibrated glucose concentration information; and

a second device configured to wirelessly receive the uncalibrated sensor data associated with the data stream from the first device, the second device having second device electronics comprising a display, a second processor and software stored in computer memory,

wherein the software comprises instructions, when executed by the second processor, to retrospectively convert the uncalibrated sensor data associated with the data stream to generate historical calibrated glucose concentration information using a retrospectively-generated conversion function and to cause display of the historical calibrated glucose concentration information on the display, and

wherein the prospectively-generated conversion function is different from the retrospectively-generated conversion function.

2. The system of claim 1, wherein at least one of the sensor electronics or the second device electronics is configured to store the uncalibrated sensor data and the calibrated sensor data in computer memory, wherein the calibrated sensor data is generated by calibrating the uncalibrated sensor data using the prospectively-generated conversion function or the retrospectively-generated conversion function.

3. The system of claim 2, wherein the calibrated sensor data comprises at least one of trend sensor information or graphical sensor information.

4. The system of claim 1, wherein the software of the second device electronics further comprises instruction configured to cause the second processor to update calibration or recalibrate sensor data associated with the retrospectively-generated conversion function based on a change in sensitivity not accounted for in the prospectively-generated conversion function.

5. The system of claim 1, further comprising a reference glucose monitor, wherein calibration of sensor data comprises a compensation for a time lag between a reference glucose data measurement by the reference glucose monitor and a sensor data measurement from the continuous glucose sensor.

6. The system of claim 5, wherein the compensation comprises matching a glucose concentration measurement by the reference glucose monitor with sensor data obtained from about 5 minutes to about 20 minutes after the glucose concentration measurement by the reference glucose monitor.

7. The system of claim 6, wherein the reference glucose monitor is configured to receive a test strip having a biological sample of a host thereon.

8. The system of claim 7, wherein the test strip is substantially rectangular and comprises a capillary portion with a capillary inlet configured for receiving a blood sample.

9. The system of claim 1, wherein the software further comprises instructions configured to cause the second processor to simultaneously present, on the display, each one of a first output of the calibrated sensor data displayed simultaneously with a glucose concentration target range, a second output of at least one glucose concentration measurement by a reference glucose monitor, and a third output of a directional arrow indicative of both a direction and an amplitude of a rate of change of glucose concentration associated with the calibrated sensor data.

10. The system of claim 9, wherein the second device is configured to allow a user to toggle between a first screen comprising the first output and a second screen comprising the second output.

11. The system of claim 9, wherein the glucose concentration target range is defined on the display by at least one of a shaded region or a colored region.

12. The system of claim 9, wherein the glucose concentration target range is represented by an upper boundary and a lower boundary.

13. The system of claim 9, wherein the upper boundary and the lower boundary are user configurable.

14. The system of claim 1, wherein the second device is configured to transmit a request to the sensor electronics module and wherein the sensor electronics module is configured to transmit sensor data to the phone in response to the sensor electronics module receiving the request.

15. The system of claim 1, wherein the second device is configured to establish a communication link with the first device responsive to a user initiation.

16. The system of claim 1, wherein the second device is a hand-held device.

17. The system of claim 1, wherein the second device is a cell phone.

18. The system of claim 1, wherein the first device is an on-skin device.

19. The system of claim 1, wherein the continuous glucose sensor comprises a sensing region and a sensing membrane located over the sensing region, and wherein at least a portion of the continuous glucose sensor is configured for transcutaneous insertion through a skin of a host.

20. The system of claim 1, wherein the second device is configured to download the software onto the second device via a data communication port or a wireless receiver.