Detection, screening, and diagnosis of HPV-associated cancers

  • US 8,968,995 B2
  • Filed: 11/12/2009
  • Issued: 03/03/2015
  • Est. Priority Date: 11/12/2008
  • Status: Active Grant
First Claim
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1. A method of assessing the correlation of HPV infection to a variety of cancers and carcinomas in a clinical sample from a human subject, comprising:

  • obtaining a clinical sample from a source sample other than cervical sample;

    conducting one or more detection assays on the clinical sample from the human subject using a monoclonal antibody that specifically binds to two or more native HPV proteins from different HPV types, whereinthe two or more native HPV proteins are native E7 proteins from different HPV types and/or native E6 proteins from different HPV types, andthe monoclonal antibody is capable of binding in situ to the native HPV proteins in the clinical sample;

    detecting a presence of an HPV protein in the clinical sample based at least in part upon a result of conducting the one or more detection assays on the clinical sample;

    assigning a score based on the level of the presence of the HPV protein in the clinical sample; and

    determining the correlation of HPV infection to a variety of cancers and carcinomas in the human subject based at least in part upon a result of detecting the presence of the HPV protein in the clinical sample.

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