Extracellular vesicles derived from gram-positive bacteria, and use thereof

  • US 8,969,653 B2
  • Filed: 08/26/2010
  • Issued: 03/03/2015
  • Est. Priority Date: 09/01/2009
  • Status: Active Grant
First Claim
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1. A method of causing to induce antibody production or a T cell immune response against Gram-positive bacteria, the method comprising:

  • isolating extracellular vesicles from Gram-positive bacteria with a cell wall, the extracellular vesicles comprising a biological substance of the Gram-positive bacteria; and

    providing a composition comprising extracellular vesicles and a pharmaceutically acceptable carrier for administering the composition to a subject in need of such induction at a sublethal dose,wherein isolating comprises;

    culturing Gram-positive bacteria in a culture medium,obtaining supernatant of the culture medium by centrifugation, andfiltering the supernatant with a filter having a pore size sufficient to isolate extracellular vesicles contained in the supernatant.

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