Method and device for displaying predicted volume of influence with patient-specific atlas of neural tissue

• US 8,983,155 B2
• Filed: 09/14/2012
• Issued: 03/17/2015
• Est. Priority Date: 07/07/2004
• Status: Active Grant

• Current Assignee: Cleveland Clinic Foundation
• Original Assignee: Cleveland Clinic Foundation
• Inventors: McIntyre, Cameron C., Butson, Christopher R., Hall, John D., Henderson, Jaimie M.
• Primary Examiner(s): Patel, Jayesh A
• Application Number:
  US13/573,439
• Publication Number:
  US 20130030276A1
• Time in Patent Office: 914 Days
• Field of Search: None
• US Class Current: 382/128
• CPC Class Codes: A61B 2090/364 Correlation of different images or relation of image positions in respect to the body
• CPC Class Codes: A61B 5/24 Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
• CPC Class Codes: A61B 90/37 Surgical systems with images on a monitor during operation
• CPC Class Codes: A61N 1/0529 Electrodes for brain stimulation
• CPC Class Codes: A61N 1/0531 Brain cortex electrodes
• CPC Class Codes: A61N 1/0534 Electrodes for deep brain stimulation
• CPC Class Codes: A61N 1/0539 Anchoring of brain electrode systems, e.g. within burr hole
• CPC Class Codes: A61N 1/36082 Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
• CPC Class Codes: A61N 1/36135 using physiological parameters
• CPC Class Codes: A61N 1/36146 specified by the stimulation parameters
• CPC Class Codes: G16H 20/30 relating to physical therapies or activities, e.g. physiotherapy, acupressure or exercising
• CPC Class Codes: G16H 30/20 for handling medical images, e.g. DICOM, HL7 or PACS
• CPC Class Codes: G16H 50/50 for simulation or modelling of medical disorders

Abstract

This document discusses, among other things, brain stimulation models, systems, devices, and methods, such as for deep brain stimulation (DBS) or other electrical stimulation. In an example, volumetric imaging data representing an anatomical volume of a brain of a patient can be obtained and transformed to brain atlas data. A patient-specific brain atlas can be created using the inverse of the transformation to map the brain atlas data onto the volumetric imaging data and a volume of influence can be calculated using the patient-specific brain atlas. In certain examples, the volume of influence can include a predicted volume of tissue affected by an electrical stimulation delivered by an electrode at a corresponding at least one candidate electrode target location.

Claims

1. A computer-implemented method of outputting information concerning an electrode inserted inside a patient'"'"'s neural tissue, the method comprising:

determining, by a computer processor, a distribution of electrical values, to be generated by the inserted electrode, in the patient'"'"'s neural tissue in a region surrounding the inserted electrode;

determining at least one threshold electrical value for neural tissue activation;

determining, by the processor and by applying the at least one threshold value to the electrical values, an estimated volume of neural tissue activated by the distribution of electrical values; and

displaying, by the processor, a graphical representation of the determined estimated volume relative to an anatomical atlas that is specific to the patient and is generated by;

registering imaging data representing an anatomy of the patient'"'"'s neural tissue to a canonical anatomical atlas by performing a transformation; and

performing an inverse of the transformation on the canonical anatomical atlas.

2. The method of claim 1, further comprising generating a model of a spatial arrangement of neural elements, wherein the determining of the estimated volume of neural tissue activated is performed by applying the determined distribution of electrical values to the model of the spatial arrangement of neural elements.

3. The method of claim 1, further comprising determining conductivity at a plurality of tissue regions, wherein the determination of the distribution of electrical values is based on the determined conductivity.

4. The method of claim 3, wherein the plurality of tissue regions span an anatomical area across which the determined conductivity is inhomogeneous.

5. The method of claim 3, wherein the plurality of tissue regions span an anatomical area across which the determined conductivity is anisotropic.

6. The method of claim 3, wherein the determined conductivity is patient specific.

7. The method of claim 3, wherein the conductivity is determined based on diffusivity in the plurality of tissue regions.

8. A computer-implemented method of outputting information concerning an electrode inserted inside a patient'"'"'s neural tissue, the method comprising:

determining, by a computer processor, a distribution of electrical values, to be generated by the inserted electrode, in the patient'"'"'s neural tissue in a region surrounding the inserted electrode;

generating a model of a spatial arrangement of neural elements;

determining at least one threshold electrical value for neural tissue activation;

determining, by the processor and by applying (a) the determined distribution of electrical values to the model of the spatial arrangement of neural elements and (b) the at least one threshold value to the electrical values, an estimated volume of neural tissue activated by the distribution of electrical values; and

outputting, by the processor, a graphical representation of the determined estimated volume.

9. The method of claim 8, further comprising determining conductivity at a plurality of tissue regions, wherein the determination of the distribution of electrical values is based on the determined conductivity.

10. A computer-implemented method of outputting information concerning an electrode inserted inside a patient'"'"'s neural tissue, the method comprising:

determining, by a computer processor, an electric field in the patient'"'"'s neural tissue, the electric field to be generated by the electrode;

determining electrical conductivity at a plurality of tissue regions;

applying the determined electrical conductivity to a model of a spatial arrangement of neural elements to determine a behavior of the neural elements of the model of the spatial arrangement of neural elements;

determining, by the processor, by applying the determined electric field to the model of the spatial arrangement of neural elements, and based on the determined behavior of the neural elements, an estimated volume of neural tissue activated by the determined electric field; and

outputting, by the processor, a graphical representation of the determined estimated volume.

11. The method of claim 10, wherein the electrical conductivity is determined based on diffusion tensor imaging.

12. The method of claim 10, wherein the electrical conductivity is non-homogeneous and anisotropic.

13. The method of claim 10, further comprising:

obtaining a finite element model of nodes of an anatomical region; and

applying the determined electrical conductivity information to the nodes of the finite element model, wherein the applying of the determined electrical conductivity to the model of the spatial arrangement of neural elements includes applying the finite element model, including the determined electrical conductivity information applied thereto, to the model of the spatial arrangement of neural elements.

14. The method of claim 10, wherein the outputting includes displaying the graphical representation relative to an anatomical atlas that is specific to the patient and is generated by:

registering imaging data representing an anatomy of the patient'"'"'s neural tissue to a canonical anatomical atlas by performing a transformation; and

performing an inverse of the transformation on the canonical anatomical atlas.

15. The method of claim 14, wherein the electrical conductivity is determined based on diffusion tensor imaging.

16. The method of claim 14, wherein the electrical conductivity is inhomogeneous and anisotropic.

17. The method of claim 14, further comprising:

obtaining a finite element model of nodes of an anatomical region; and

applying the determined electrical conductivity information to the nodes of the finite element model, wherein the applying of the determined electrical conductivity to the model of the spatial arrangement of neural elements includes applying the finite element model, including the determined electrical conductivity information applied thereto, to the model of the spatial arrangement of neural elements.

18. A computer-implemented method of outputting information concerning an electrode inserted inside a patient'"'"'s neural tissue, the method comprising:

determining, by a computer processor, an electric field in the patient'"'"'s neural tissue, the electric field to be generated by the electrode;

generating a patient-specific model of a spatial arrangement of neural elements;

determining, by the processor and by applying the determined electric field to the model of the spatial arrangement of neural elements, an estimated volume of neural tissue activated by the determined electric field; and

outputting, by the processor, a graphical representation of the determined estimated volume.

19. The method of claim 18, wherein the patient-specific model is generated using patient-specific imaging data.

20. The method of claim 18, wherein the patient-specific model is generated using patient-specific tensor imaging data.

21. The method of claim 18, wherein the outputting includes displaying the graphical representation relative to an anatomical atlas that is specific to the patient and is generated by:

registering imaging data representing an anatomy of the patient'"'"'s neural tissue to a canonical anatomical atlas by performing a transformation; and

performing an inverse of the transformation on the canonical anatomical atlas.

22. The method of claim 21, wherein the patient-specific model is generated using patient-specific imaging data.

23. The method of claim 21, wherein the patient-specific model is generated using patient-specific tensor imaging data.

24. A computer-implemented method of outputting information concerning an electrode inserted inside a patient'"'"'s neural tissue, the method comprising:

determining, by a computer processor, conductivity at a plurality of tissue regions that span an anatomical area across which the determined conductivity is anisotropic;

determining, by the processor and based on the determined conductivity, a distribution of electrical values, to be generated by the inserted electrode, in the patient'"'"'s neural tissue in a region surrounding the inserted electrode;

determining at least one threshold electrical value for neural tissue activation;

determining, by the processor and by applying the at least one threshold value to the electrical values, an estimated volume of neural tissue activated by the distribution of electrical values; and

outputting, by the processor, a graphical representation of the determined estimated volume.

25. The method of claim 24, wherein the determined conductivity is patient specific.

26. The method of claim 24, wherein the conductivity is determined based on diffusivity in the plurality of tissue regions.

27. The method of claim 24, wherein the determining of the distribution of electrical values and the determining of the estimated volume of neural tissue activated is performed for each of a plurality of different sets of settings for the inserted electrode, different estimated volumes of neural tissue activated being determined for the different sets of settings, a location of the electrode in the patient'"'"'s neural tissue being the same for the plurality of determinations of the estimated volume of neural tissue activated.

28. The method of claim 24, wherein the plurality of tissue regions span an anatomical area across which the determined conductivity is inhomogeneous.

29. The method of claim 24, wherein the outputting includes displaying the graphical representation relative to an anatomical atlas.

30. A computer-implemented method of outputting information concerning an electrode inserted inside a patient'"'"'s neural tissue, the method comprising:

determining, by a computer processor, a distribution of electrical values, to be generated by the inserted electrode, in the patient'"'"'s neural tissue in a region surrounding the inserted electrode;

determining a threshold second difference value of the electrical values for neural tissue activation;

determining, by the processor and by applying the threshold second difference value to the electrical values, an estimated volume of neural tissue activated by the distribution of electrical values; and

outputting, by the processor, a graphical representation of the determined estimated volume.