Analyte sensor sensitivity attenuation mitigation

• US 8,986,208 B2
• Filed: 09/30/2008
• Issued: 03/24/2015
• Est. Priority Date: 09/30/2008
• Status: Active Grant

• Current Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories Incorporated)
• Inventors: Hayter, Gary, Mazza, John C., Doniger, Kenneth J.
• Primary Examiner(s): D'ANGELO, MICHAEL J
• Application Number:
  US12/242,834
• Publication Number:
  US 20100081906A1
• Time in Patent Office: 2,366 Days
• Field of Search: 600345-347, 600/365
• US Class Current: 600/365
• CPC Class Codes: A61B 2505/07 Home care
• CPC Class Codes: A61B 2560/0223 of calibration, e.g. protocols for calibrating sensors
• CPC Class Codes: A61B 2560/0481 in implanted apparatus
• CPC Class Codes: A61B 2562/043 in a linear array
• CPC Class Codes: A61B 2562/046 in a matrix array
• CPC Class Codes: A61B 5/002 Monitoring the patient using a local or closed circuit, e.g. in a room or building A61B5/0017 takes precedence
• CPC Class Codes: A61B 5/1451 for interstitial fluid
• CPC Class Codes: A61B 5/14517 for sweat
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14542 for measuring blood gases A61B5/14551 takes precedence
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1468 using chemical or electrochemical methods, e.g. by polarographic means A61B5/1486 takes precedence
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes
• CPC Class Codes: A61B 5/7221 Determining signal validity, reliability or quality A61B5/7207 and A61B5/7217 take precedence

Abstract

Method and apparatus for receiving a first signal from a first working electrode of a glucose sensor positioned at a first predetermined position under the skin layer, receiving a second signal from a second working electrode of the glucose sensor positioned at a second predetermined position under the skin layer, the second signal received substantially contemporaneous to receiving the first signal, detecting a dropout in the signal level associated with one of the first or second signals, comparing the first signal and the second signal to determine a variation between the first and second signals, and confirming one of the first or second signals as a valid glucose sensor signal output when the determined variation between the first and the second signals is less than a predetermined threshold level are provided.

Claims

1. An apparatus, comprising:

a data communication interface;

one or more processors coupled to the data communication interface; and

a memory storing instructions which, when executed by the one or more processors, receives a first signal from a first working electrode of a glucose sensor positioned at a first predetermined position under a skin layer, receives a second signal from a second working electrode of the glucose sensor positioned at a second predetermined position under the skin layer, the second signal received contemporaneously to receiving the first signal, detects a dropout in a signal level associated with one of the first signal or the second signal, compares the first signal and the second signal to determine a variation between the first signal and the second signal in response to detecting the dropout in the signal level, and confirming the one of the first signal or the second signal as a valid glucose sensor signal when the determined variation between the first signal and the second signal is less than a predetermined threshold level.

2. The apparatus of claim 1, wherein when the variation between the first signal and the second signal exceeds the predetermined threshold level, the memory storing instructions which, when executed by the one or more processors, confirms both of the first signal or the second signal as invalid sensor output signals.

3. The apparatus of claim 1, wherein when the variation between the first signal and the second signal exceeds the predetermined threshold level, the memory storing instructions which, when executed by the one or more processors, performs a rate of change determination of signals from one of the first working electrode or the second working electrode, and confirms the one of the first signal or the second signal as the valid glucose sensor signal when the determined rate of change level is less than a predetermined rate threshold level.

4. The apparatus of claim 3, wherein, when the determined rate of change level is greater than the predetermined rate threshold level, the memory storing instructions which, when executed by the one or more processors, confirms both of the first signal and the second signal from the first working electrode and the second working electrode, respectively as invalid sensor signals.

5. An apparatus, comprising:

means for receiving a first signal from a first working electrode of a glucose sensor positioned at a first predetermined position under a skin layer;

means for receiving a second signal from a second working electrode of the glucose sensor positioned at a second predetermined position under the skin layer, the second signal received contemporaneously to receiving the first signal;

means for detecting a dropout in a signal level associated with one of the first signal or the second signal;

means for comparing the first signal and the second signal to determine a variation between the first signal and the second signal in response to detecting the dropout in the signal level; and

means for confirming the one of the first signal or the second signal as a valid glucose sensor signal when the determined variation between the first signal and the second signal is less than a predetermined threshold level.