Method and composition for transdermal drug delivery

  • US 8,993,520 B2
  • Filed: 06/25/2010
  • Issued: 03/31/2015
  • Est. Priority Date: 06/03/2005
  • Status: Active Grant
First Claim
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1. A method of increasing the testosterone blood level of an adult male subject in need thereof comprising applying to at least one axilla of the subject, without occlusion by a patch device, a transdermal drug delivery composition comprising:

  • (a) a pharmaceutically effective amount of testosterone;

    (b) one or more lower alkyl alcohols, wherein the combined amount of lower alkyl alcohols is more than 60% v/v of the composition;

    (c) one or more penetration enhancers selected from the group consisting of oleic acid, fatty acid esters, fatty alcohols, glycols, glycol esters, 1,3-dioxolanes, 1,3-dioxanes, macrocyclic ketones containing at least 12 carbon atoms, oxazolidinones, alkyl-2-(N,N-disubstituted amino)-alkanoate esters, (N,N-disubstituted amino)-alkanol alkanoates, sunscreen esters and mixtures thereof; and

    (d) a viscosity modulating agent for increasing the viscosity of the composition.

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