Natural combination hormone replacement formulations and therapies

  • US 8,993,549 B2
  • Filed: 09/03/2014
  • Issued: 03/31/2015
  • Est. Priority Date: 11/23/2011
  • Status: Active Grant
First Claim
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1. A pharmaceutical composition comprising:

  • solubilized estradiol;

    suspended progesterone; and

    a solubilizing agent;

    wherein each of the estradiol and the suspended progesterone are present in the solubilizing agent and the estradiol and progesterone are uniformly dispersed;

    wherein at least about 90% of the estradiol is solubilized in the solubilizing agent; and

    wherein the solubilizing agent comprises an effective amount of a monoglyceride, a diglyceride or a combination thereof containing an ester of a C6-C12 fatty acid.

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