Method of component concentration detection based on reference wavelength

• US 8,996,338 B2
• Filed: 06/03/2009
• Issued: 03/31/2015
• Est. Priority Date: 06/06/2008
• Status: Active Grant

• Current Assignee: Tianjin Sunrise Technologies Development Co., Ltd.
• Original Assignee: Tianjin Sunrise Technologies Development Co., Ltd.
• Inventors: Xu, Kexin, Chen, Wenliang
• Primary Examiner(s): Saxena, Akash
• Application Number:
  US12/996,089
• Publication Number:
  US 20110131021A1
• Time in Patent Office: 2,127 Days
• Field of Search: 600/316, 703/2
• US Class Current: 703/2
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: G01N 21/359 using near infrared light

Abstract

A method of detecting a concentration of a target component by using a reference wavelength includes: defining a wavelength at which a light intensity is insensitive to the variation of the target component concentration as a reference wavelength for the target component; detecting spectra at both the reference wavelength and a further measuring wavelength; processing the spectrum detected at the further measuring wavelength, with the spectrum detected at the reference wavelength as an inner reference, to obtain a characteristic spectrum including specific information of the target component; building a calibration model between the characteristic spectrum and the concentration of the target component; and determining the concentration of the target component based on the calibration model.

Claims

1. A method of detecting a concentration of a target component in a sample, including steps of:

1) defining a wavelength at which a light intensity is insensitive to variation of the target component concentration as a reference wavelength for the target component;

2) detecting spectra at the reference wavelength and a further measuring wavelength;

3) processing the spectrum detected at the further measuring wavelength, with the spectrum detected at the reference wavelength as an inner reference, to obtain a characteristic spectrum including specific information of the target component;

4) building a calibration model between the characteristic spectrum and the concentration of the target component; and

5) determining the concentration of the target component based on the calibration model,

wherein the reference wavelength λ

_r is defined as follows;

for a pure absorption sample, α

_g(λ

_r)+α

_w(λ

_r)·

k=0; and

for a scattering sample,

2. The method according to claim 1, wherein the reference wavelength for the glucose in the aqueous glucose solution is 1525 nm.

3. The method according to claim 1, wherein a wavelength at which light intensity is most sensitive to the variation of the target component concentration is selected as the measuring wavelength.

4. The method according to claim 1, wherein in step 3), the specific information of the target component is obtained as follows:

for a pure absorption sample, the specific information including the variation of the target component concentration is;

5. The method according to claim 1, wherein the calibration model is built by the Partial Least Squares (PLS) method or the net analyte signal method.