Layered sensor for determining an analyte concentration

• US 8,997,330 B2
• Filed: 10/31/2012
• Issued: 04/07/2015
• Est. Priority Date: 12/19/2005
• Status: Active Grant

• Current Assignee: Roche Diabetes Care Inc. (Roche Holding AG)
• Original Assignee: Roche Diagnostics Operations Incorporated (Roche Holding AG)
• Inventors: Kotzan, Holger, Bainczyk, Gregor
• Primary Examiner(s): TRINH, MINH N
• Application Number:
  US13/664,757
• Publication Number:
  US 20130056144A1
• Time in Patent Office: 888 Days
• Field of Search: 29830-831, 29846-847, 298/74, 295/921, 204/403.01, 600/345
• US Class Current: 29/592.1
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: A61B 5/6848 Needles
• CPC Class Codes: C12Q 1/006 for glucose
• CPC Class Codes: Y10T 156/1052 with cutting, punching, tearing or severing
• CPC Class Codes: Y10T 29/49002 Electrical device making
• CPC Class Codes: Y10T 29/49007 Indicating transducer
• CPC Class Codes: Y10T 29/49117 Conductor or circuit manufacturing
• CPC Class Codes: Y10T 29/49155 Manufacturing circuit on or in base

Abstract

An implantable sensor is provide which can be used for determining a concentration of at least one analyte in a medium, in particular a body tissue and/or a body fluid. The implantable sensor has a layered construction with at least one insulating carrier substrate and at least two electrodes which are arranged in at least two different layer planes of the implantable sensor and are electrically isolated from one another by the at least one insulating carrier substrate. The electrodes have electrode areas which face the medium when the sensor has been implanted, and are in contact with the medium over a large area and substantially uniformly, directly or via a generally analyte-permeable membrane layer.

Claims

1. A method for producing implantable sensors for determining an analyte concentration in a body tissue or a body fluid, the method comprising the steps of:

applying a first metal layer substantially over a first plane of a carrier film and a second metal layer substantially over a second plane of the carrier film, the first and second metal layers directly contacting the carrier film, wherein the first and second metal layers comprise first and second electrode contact layers and the first and second planes are spaced apart on the carrier film, the carrier film comprising an insulating material;

providing first and second electrode systems on the respective first and second electrode contact layers; and

cutting the carrier film into a plurality of strips, wherein each strip comprises an implantable sensor.

2. The method according to claim 1, further comprising applying the first and second metal layers according to a method selected from the group consisting of:

a lamination method, a reel-to-reel film method, a PVD method, a CVD method, and a wet-chemical coating method.

3. The method according to claim 1, wherein the first electrode system is applied to one of the two electrode contact layers on the side remote from the carrier film, and the second electrode system is applied to the other of the two electrode contact layers on the side remote from the carrier film.

4. The method according to claim 3, further comprising:

providing a second carrier film;

coating one side of the second carrier film with a third electrode contact layer;

applying a third electrode system to the third electrode contact layer; and

applying the side of the second carrier film remote from the third electrode contact layer to the first carrier film such that at least one step is formed.

5. The method according to claim 1 further comprising applying at least one insulator layer at least partially over each metal layer.

6. A method for producing implantable sensors for determining an analyte concentration in a body tissue or a body fluid, the method comprising:

applying a first metal layer substantially over a first plane of a carrier film and a second metal layer substantially over a second plane of the carrier film, wherein the first and second metal layers comprise first and second electrode contact layers and the first and second planes are spaced apart on the carrier film, the carrier film comprising an insulating material;

then

providing first and second electrode systems on the respective first and second electrode contact layers; and

cutting the carrier film into a plurality of strips, wherein each strip comprises an implantable sensor.