Apparatus and method for influencing and/or detecting magnetic particles in a field of view having an array of single-sided transmit coil sets

• US 9,008,749 B2
• Filed: 01/28/2011
• Issued: 04/14/2015
• Est. Priority Date: 02/08/2010
• Status: Expired due to Fees

• Current Assignee: Koninklijke Philips N.V.
• Original Assignee: Koninklijke Philips N.V.
• Inventors: Buzug, Thorsten Manuel, Sattel, Timo Frederik, Knopp, Tobias, Biederer, Sven
• Primary Examiner(s): Le, Long V
• Assistant Examiner(s): Sakamoto, Colin T
• Application Number:
  US13/576,757
• Publication Number:
  US 20120310076A1
• Time in Patent Office: 1,537 Days
• Field of Search: 600/409
• US Class Current: 600/409
• CPC Class Codes: A61B 5/05 Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves impedance plethysmography A61B5/0295; measuring movement of the entire body or parts thereof A61B5/11; detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof A61B5/24
• CPC Class Codes: A61B 5/0515 Magnetic particle imaging

Abstract

The present invention relates to an apparatus and a method for influencing and/or detecting magnetic particles in a field of view. To increase the field of view and, at the same time, allow access to the patient during imaging, the apparatus comprises two or more transmit coil sets (200) wherein neighboring coil sets are partially overlapping, a transmit coil set comprising: a pair (210) of concentrically arranged selection field coils (211, 212) for generating a magnetic selection field (50) having a pattern in space of its magnetic field strength such that a first sub-zone (52) having a low magnetic field strength and a second sub-zone (54) having a higher magnetic field strength are formed in the field of view (28), and at least one pair (220, 230) of drive field coils (221, 222; 231, 232) for changing the position in space of the two sub-zones (52, 54) in the field of view (28) by means of a magnetic drive field so that the magnetization of the magnetic particles changes locally, said at least one pair (220, 230) of drive field coils being arranged parallel to said pair (210) of selection field coils (211, 212) and being formed by two neighboring coil loops.

Claims

1. An apparatus for influencing and/or detecting magnetic particles in a field of view, which apparatus comprises:

i) two or more transmit coil sets, wherein neighboring transmit coil sets are partially overlapping, each transmit coil set comprising;

a pair of coplanar, concentrically arranged selection field coils for generating a magnetic selection field having a pattern in space of its magnetic field strength such that a first sub-zone having a low magnetic field strength and a second sub-zone having a higher magnetic field strength are formed in the field of view, and

at least one pair of drive field coils for changing the position in space of the two sub-zones in the field of view by means of a magnetic drive field so that the magnetization of the magnetic particles changes locally, said at least one pair of drive field coils being arranged parallel to said pair of selection field coils and being formed by two neighboring coil loops having adjacent segments, the adjacent segments being angularly offset from adjacent segments of a neighboring pair of drive field coils,

ii) generator means for generating current signals for provision to said selection field coils and said drive field coils for generating desired magnetic fields by said coils, and

iii) control means for controlling said generator means to generate direct currents of opposite directions for provision to the two selection field coils of said pair of selection field coils and alternate currents of opposite directions for provision to the two drive field coils of said at least one pair of drive field coils

wherein the control means is configured to control said generator means to generate currents for provision to the coils of the transmit coil sets such that for transfer of the first sub-zone from a first transmit coil set to a second transmit coil set the first sub-zone is driven to the border of the field of view of the first transmit coil set, the magnetic selection field of the first transmit coil set is decreased and the magnetic selection field of the second transmit coil set is increased.

2. An apparatus as claimed in claim 1,

wherein the adjacent segments are angularly offset from adjacent segments of the neighboring pair of drive field coils by a rotation angle (α

) greater than 0° and

less than 180°

.

3. An apparatus as claimed in claim 2,

wherein the adjacent segments are angularly offset from the adjacent segments of the neighboring pair of drive field coils by a rotation angle (α

) in the range between 75° and

105°

.

4. An apparatus as claimed in claim 2,

wherein said control means is adapted for controlling said generator means to generate alternate currents of opposite directions for provision to the two selection field coils of said pair of selection field coils in addition to the direct currents of opposite directions.

5. An apparatus as claimed in claim 1,

wherein the at least one pair of drive field coils is formed by identical coil loops.

6. An apparatus as claimed in claim 1,

wherein a pair of drive field coils is formed by two identical neighboring D-shaped or rectangular-shaped coil loops, wherein two linear branches of said loops are directly neighboring each other.

7. An apparatus as claimed in claim 1,

wherein the two coil loops of a pair of drive field coils are arranged symmetrical to a symmetry plane going through a coil axis to which said selection field coils are arranged concentric.

8. An apparatus as claimed in claim 1,

wherein the pair of selection field coils and the at least one pair of drive field coils of a transmit coil set have substantially identical outer dimensions and are disk-like arranged above each other.

9. An apparatus as claimed in claim 1, further comprising

iv) receiving means comprising at least one receiving coil for acquiring detection signals, which detection signals depend on the magnetization in the field of view, which magnetization is influenced by the change in the position in space of the first and second sub-zone, and

v) processing means for processing said detection signals, in particular for reconstructing an image from said detection signals and/or for localizing said magnetic particles within the field of view, in particular within an object placed within the field of view.

10. An apparatus as claimed in claim 1,

comprising a plurality of transmit coil sets, which are equidistantly spaced and substantially arranged within one or more flat or curved planes.

11. An apparatus as claimed in claim 1, wherein the transfer of the first sub-zone from a first transmit coil set to a second transmit coil allows a field-free point having a magnetic gradient field of zero to be operated continuously between partially overlapping transmit coil sets.

12. An apparatus as claimed in claim 1,

wherein the control means is adapted for controlling said generator means to generate currents for provision to the coils of the transmit coil sets such that two or more first sub-zones are generated and simultaneously moved.

13. A method for influencing and/or detecting magnetic particles in a field of view, which method comprises the steps of:

i) generating magnetic fields by two or more transmit coil sets, wherein neighboring transmit coil sets are partially overlapping, said step of generating magnetic fields comprising;

generating a magnetic selection field having a pattern in space of its magnetic field strength such that a first sub-zone having a low magnetic field strength and a second sub-zone having a higher magnetic field strength are formed in the field of view by a pair of coplanar, concentrically arranged selection field coils and

changing the position in space of the two sub-zones in the field of view by means of a magnetic drive field so that the magnetization of the magnetic particles changes locally by at least one pair of drive field coils, said at least one pair of drive field coils being arranged parallel to said pair of selection field coils and being formed by two neighboring coil loops having adjacent segments, the adjacent segments being angularly offset from adjacent segments of a neighboring pair of drive field coils,

ii) generating, with a generator means, current signals for provision to said selection field coils and said drive field coils for generating desired magnetic fields by said coils, and

iii) controlling, with a control means, said generator means to generate direct currents of opposite directions for provision to the two selection field coils of said pair of selection field coils and alternate currents of opposite directions for provision to the two drive field coils of said at least one pair of drive field coils wherein the control means is configured to control said generator means to generate currents for provision to the coils of the transmit coil sets such that for transfer of the first sub-zone from a first transmit coil set to a second transmit coil set the first sub-zone is driven to the border of the field of view of the first transmit coil set, the magnetic selection field of the first transmit coil set is decreased and the magnetic selection field of the second transmit coil set is increased.

14. A non-transitory computer readable storage medium comprising a computer readable program for influencing and/or detecting magnetic particles in a field of view, wherein the computer readable program when executed on a computer causes the computer to perform the steps of claim 13, wherein the computer is the control means.